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Title: Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
Authors: Marques, Joana
Valle-Delgado, Juan José
Urbán, Patricia
Baró, Elisabet
Prohens, Rafel
Mayor, Alfredo
Cisteró, Pau
Delves, Michael
Sinden, Robert E
Grandfils, Christian
de Paz, José L
García-Salcedo, José A
Fernàndez-Busquets, Xavier
metadata.dc.contributor.authoraffiliation: [Marques,J; Valle-Delgado,JJ; Urbán,P; Baró,E; Fernàndez-Busquets,X] Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain. Barcelona Institute for Global Health (ISGlobal), Barcelona Center for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain. Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, Barcelona, Spain. [Prohens,R] Unitat de Polimorfisme i Calorimetria, Centres Científics i Tecnològics, Universitat de Barcelona, Barcelona, Spain. [Mayor,A; Cisteró,P] Barcelona Institute for Global Health (ISGlobal), Barcelona Center for International Health Research (CRESIB, Hospital Clínic-Universitat de Barcelona), Barcelona, Spain. [Delves,M; Sinden,RE] Department of Life Sciences, Imperial College, South Kensington, London, UK. [Grandfils,C] Interfacultary Research Center of Biomaterials (CEIB), University of Liège, Chemistry Institute, Liège (Sart-Tilman), Belgium. [de Paz,JL] Instituto de Investigaciones Químicas (IIQ) CSIC-US, Centro de Investigaciones Científicas Isla de La Cartuja, Sevilla, Spain. [García-Salcedo,JA] Unidad de Enfermedades Infecciosas y Microbiología, Instituto de Investigación Biosanitaria ibs. Granada, Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.
Keywords: Glycosaminoglycans;Malaria;Nanomedicine;Plasmodium;Targeted drug delivery;Quitosano;Recuento de eritrocitos;Antimaláricos;Insectos vectores;Heparina
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Antiparasitic Agents::Antiprotozoal Agents::Antimalarials
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Chitin::Chitosan
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Glycosaminoglycans::Chondroitin::Chondroitin Sulfates
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Count::Blood Cell Count::Erythrocyte Count
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Blood::Blood Cells::Erythrocytes
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Glycosaminoglycans::Heparin
Medical Subject Headings::Chemicals and Drugs::Lipids
Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations::Dosage Forms::Drug Carriers::Liposomes
Medical Subject Headings::Diseases::Parasitic Diseases::Protozoan Infections::Malaria
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Transmission, Infectious::Disease Vectors::Arthropod Vectors::Insect Vectors::Mosquito Vectors
Medical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Nanotechnology
Medical Subject Headings::Organisms::Eukaryota::Alveolata::Apicomplexa::Haemosporida::Plasmodium
Medical Subject Headings::Organisms::Eukaryota::Animals
Issue Date: Feb-2017
Publisher: Elsevier
Citation: Marques J, Valle-Delgado JJ, Urbán P, Baró E, Prohens R, Mayor A et al.Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery. Nanomedicine. 2017 Feb;13(2):515-525
Abstract: The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.
Description: Patent application: Heparin-lipidic nanoparticle conjugates. Inventors: Fernàndez-Busquets, X., Marques, J., Moles, E. Institutions: IBEC, ISGlobal. Application number: EP13152187.4; priority country: Europe; priority date: January 22, 2013.
metadata.dc.identifier.doi: 10.1016/j.nano.2016.09.010
ISSN: 1549-9634 (Print)
1549-9642 (Online)
Appears in Collections:01- Artículos - Complejo Hospitalario Universitario de Granada
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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