Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2614
Título : Global dissemination of a multidrug resistant Escherichia coli clone
Autor : Petty, Nicola K
Ben Zakour, Nouri L
Stanton-Cook, Mitchell
Skippington, Elizabeth
Totsika, Makrina
Forde, Brian M
Phan, Minh-Duy
Gomes Moriel, Danilo
Peters, Kate M
Davies, Mark
Rogers, Benjamin A
Dougan, Gordon
Rodriguez-Baño, Jesús
Pascual, Alvaro
Pitout, Johann D D
Upton, Mathew
Paterson, David L
Walsh, Timothy R
Schembri, Mark A
Beatson, Scott A
Filiación: [Petty,NK; Ben Zakour,NL; Stanton-Cook,M; Skippington,E; Totsika,M; Forde,BM; Phan,BM; Gomes Moriel,D; Peters,KM; Davies,M; Paterson,DL; Schembri,MA; Beatson,SA] Australian Infectious Diseases Research Centre, Brisbane, Australia. [Petty,NK; Ben Zakour,NL; Stanton-Cook,M; Skippington,E; Totsika,M; Forde,BM; Phan,BM; Gomes Moriel,D; Peters,KM; Davies,M; Schembri,MA; Beatson,SA] School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Australia. [Petty,NK] The ithree institute, University of Technology Sydney, Sydney, Australia. [Davies,M; Dougan,G] Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom. [Rogers,BA; Paterson,DL] University of Queensland Centre for Clinical Research, Royal Brisbane and Women’s Hospital Campus, The University of Queensland, Brisbane, Australia. [Rodriguez-Baño,J; Pascual,A] Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain; Departmentos de Medicina y Microbiología, Universidad de Sevilla, Seville, Spain. [Pitout,JDD] Division of Microbiology, Calgary Laboratory Services, Calgary, Canada; Department of Pathology and Laboratory Medicine, and Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Canada. [Upton,M] School of Biomedical and Healthcare Sciences, Plymouth University, Plymouth, United Kingdom. [Walsh,TR] School of Medicine, Cardiff University, Cardiff, United Kingdom.
Palabras clave : Bacterial evolution
Genomics
Phylogeography
Genomic epidemiology
Secuencia de bases
Farmacorresistencia bacteriana múltiple
Escherichia coli
Fluoroquinolonas
MeSH: Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Base Sequence
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology
Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Bacterial Physiological Phenomena::Drug Resistance, Bacterial::Drug Resistance, Multiple, Bacterial
Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Gram-Negative Facultatively Anaerobic Rods::Enterobacteriaceae::Escherichia::Escherichia coli
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines::Quinolones::Fluoroquinolones
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome, Microbial::Genome, Bacterial
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Likelihood Functions
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Biological::Models, Genetic
Medical Subject Headings::Information Science::Information Science::Information Services::Documentation::Molecular Sequence Data
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genetics, Population::Phylogeography
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Alignment
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNA
Medical Subject Headings::Phenomena and Processes::Biological Phenomena::Species Specificity
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Amidohydrolases::beta-Lactamases
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phylogeny
Fecha de publicación : 15-Apr-2014
Editorial : National Academy of Sciences
Cita Bibliográfica: Petty NK, Ben Zakour NL, Stanton-Cook M, Skippington E, Totsika M, Forde BM, Phan MD, et al. Global dissemination of a multidrug resistant Escherichia coli clone. Proc Natl Acad Sci U S A. 2014;111(15):5694-9.
Abstract: Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR) clone responsible for a high proportion of urinary tract and bloodstream infections. The rapid emergence and successful spread of E. coli ST131 is strongly associated with several factors, including resistance to fluoroquinolones, high virulence gene content, the possession of the type 1 fimbriae FimH30 allele, and the production of the CTX-M-15 extended spectrum β-lactamase (ESBL). Here, we used genome sequencing to examine the molecular epidemiology of a collection of E. coli ST131 strains isolated from six distinct geographical locations across the world spanning 2000-2011. The global phylogeny of E. coli ST131, determined from whole-genome sequence data, revealed a single lineage of E. coli ST131 distinct from other extraintestinal E. coli strains within the B2 phylogroup. Three closely related E. coli ST131 sublineages were identified, with little association to geographic origin. The majority of single-nucleotide variants associated with each of the sublineages were due to recombination in regions adjacent to mobile genetic elements (MGEs). The most prevalent sublineage of ST131 strains was characterized by fluoroquinolone resistance, and a distinct virulence factor and MGE profile. Four different variants of the CTX-M ESBL-resistance gene were identified in our ST131 strains, with acquisition of CTX-M-15 representing a defining feature of a discrete but geographically dispersed ST131 sublineage. This study confirms the global dispersal of a single E. coli ST131 clone and demonstrates the role of MGEs and recombination in the evolution of this important MDR pathogen.
URI: http://hdl.handle.net/10668/2614
Versión del editor : http://www.pnas.org/content/111/15/5694.full.pdf
DOI: 10.1073/pnas.1322678111
ISSN : 1091-6490 (Online)
0027-8424 (Print)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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