Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2632
Título : Influence of coronary artery disease and subclinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis
Autor : López-Mejías, Raquel
Corrales, Alfonso
Vicente, Esther
Robustillo-Villarino, Montserrat
González-Juanatey, Carlos
Llorca, Javier
Genre, Fernanda
Remuzgo-Martínez, Sara
Dierssen-Sotos, Trinidad
Miranda-Filloy, José A
Ramírez Huaranga, Marco A
Pina, Trinitario
Blanco, Ricardo
Alegre-Sancho, Juan J
Raya, Enrique
Mijares, Verónica
Ubilla, Begoña
Ferraz-Amaro, Iván
Gómez-Vaquero, Carmen
Balsa, Alejandro
López-Longo, Francisco J
Carreira, Patricia
González-Álvaro, Isidoro
Ocejo-Vinyals, J Gonzalo
Rodríguez-Rodríguez, Luis
Fernández-Gutiérrez, Benjamín
Castañeda, Santos
Martín, Javier
González-Gay, Miguel A
Filiación: [López-Mejías,R; Corrales,A; Genre,F; Remuzgo-Martínez,S; Pina,T; Blanco,R; Mijares,V; Ubilla,B; González-Gay,MA] Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Department, IDIVAL, Santander, Spain. [Vicente,E; González-Álvaro,I; Castañeda,S] Rheumatology Department, Hospital Universitario la Princesa, IIS-IP, Madrid, Spain. [Robustillo-Villarino,M; Alegre-Sancho,JJ] Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain. [González-Juanatey,C] Cardiology Department, Hospital Lucus Augusti, Lugo, Spain. [Llorca,J; Dierssen-Sotos,T] Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain. [Miranda-Filloy,JA] Division of Rheumatology, Hospital Universitario Lucus Augusti, Lugo, Spain. [Ramírez Huaranga,MA] Rheumatology Department, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain. [Raya,E] Rheumatology Department, Hospital Clínico San Cecilio, Granada, Spain. [Ferraz-Amaro,I] Rheumatology Division, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain. [Gómez-Vaquero,C] Department of Rheumatology, Hospital Universitario Bellvitge, Barcelona, Spain. [Balsa,A] Department of Rheumatology, Hospital Universitario La Paz, Madrid, Spain. [López-Longo,FJ] Department of Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Carreira,P] Department of Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain. [Ocejo-Vinyals,JG] Immunology Department, Hospital Universitario Marqués de Valdecilla, Santander, Spain. [Rodríguez-Rodríguez,L; Fernández-Gutiérrez,B] Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain. [Martín,J] Instituto de Parasitología y Biomedicina ‘López-Neyra’, CSIC, PTS Granada, Granada, Spain. [González-Gay,MA] School of Medicine, University of Cantabria, Santander, Spain. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Palabras clave : Artritis reumatoide
Aterosclerosis
Enfermedades cardiovasculares
Grosor intima-media carotídeo
Enfermedad de la arteria coronaria
Genotipo
Humanos
Polimorfismo genético
Estados Unidos
Europa (Continente)
MeSH: Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, Rheumatoid
Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::Atherosclerosis
Medical Subject Headings::Diseases::Cardiovascular Diseases
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Ultrasonography::Carotid Intima-Media Thickness
Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Coronary Disease::Coronary Artery Disease
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic
Medical Subject Headings::Geographical Locations::Geographic Locations::Americas::North America::United States
Medical Subject Headings::Geographical Locations::Geographic Locations::Europe
Fecha de publicación : 6-Jan-2017
Editorial : Nature Publishing Group
Cita Bibliográfica: López-Mejías R, Corrales A, Vicente E, Robustillo-Villarino M, González-Juanatey C, Llorca J, et al. Influence of coronary artery disease and subcClinical atherosclerosis related polymorphisms on the risk of atherosclerosis in rheumatoid arthritis. Sci Rep. 2017; 7:40303
Abstract: A genetic component influences the development of atherosclerosis in the general population and also in rheumatoid arthritis (RA). However, genetic polymorphisms associated with atherosclerosis in the general population are not always involved in the development of cardiovascular disease (CVD) in RA. Accordingly, a study in North-American RA patients did not show the association reported in the general population of coronary artery disease with a series of relevant polymorphisms (TCF21, LPA, HHIPL1, RASD1-PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2). In the present study, we assessed the potential association of these polymorphisms with CVD in Southern European RA patients. We also assessed if polymorphisms implicated in the increased risk of subclinical atherosclerosis in non-rheumatic Caucasians (ZHX2, PINX1, SLC17A4, LRIG1 and LDLR) may influence the risk for CVD in RA. 2,609 Spanish patients were genotyped by TaqMan assays. Subclinical atherosclerosis was determined in 1,258 of them by carotid ultrasonography (assessment of carotid intima media thickness and presence/absence of carotid plaques). No statistically significant differences were found when each polymorphism was assessed according to the presence/absence of cardiovascular events and subclinical atherosclerosis, after adjustment for potential confounder factors. Our results do not show an association between these 15 polymorphisms and atherosclerosis in RA.
URI: http://hdl.handle.net/10668/2632
Versión del editor : http://www.nature.com/articles/srep40303#abstract
DOI: 10.1038/srep40303
ISSN : 2045-2322 Online)
Appears in Collections:01- Artículos - Complejo Hospitalario Universitario de Granada

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