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dc.contributor.authorCavagna, Lorenzo-
dc.contributor.authorNuño, Laura-
dc.contributor.authorScirè, Carlo Alberto-
dc.contributor.authorGovoni, Marcello-
dc.contributor.authorLopez Longo, Francisco Javier-
dc.contributor.authorFranceschini, Franco-
dc.contributor.authorNeri, Rossella-
dc.contributor.authorCastañeda, Santos-
dc.contributor.authorSifuentes Giraldo, Walter Alberto-
dc.contributor.authorCaporali, Roberto-
dc.contributor.authorIannone, Florenzo-
dc.contributor.authorFusaro, Enrico-
dc.contributor.authorPaolazzi, Giuseppe-
dc.contributor.authorPellerito, Raffaele-
dc.contributor.authorSchwarting, Andreas-
dc.contributor.authorSaketkoo, Lesley Ann-
dc.contributor.authorOrtego-Centeno, Norberto-
dc.contributor.authorQuartuccio, Luca-
dc.contributor.authorBartoloni, Elena-
dc.contributor.authorSpecker, Christof-
dc.contributor.authorPina Murcia, Trinitario-
dc.contributor.authorLa Corte, Renato-
dc.contributor.authorFurini, Federica-
dc.contributor.authorFoschi, Valentina-
dc.contributor.authorBachiller Corral, Javier-
dc.contributor.authorAirò, Paolo-
dc.contributor.authorCavazzana, Ilaria-
dc.contributor.authorMartínez-Barrio, Julia-
dc.contributor.authorHinojosa, Michelle-
dc.contributor.authorGiannini, Margherita-
dc.contributor.authorBarsotti, Simone-
dc.contributor.authorMenke, Julia-
dc.contributor.authorTriantafyllias, Kostantinos-
dc.contributor.authorVitetta, Rosetta-
dc.contributor.authorRusso, Alessandra-
dc.contributor.authorBajocchi, Gianluigi-
dc.contributor.authorBravi, Elena-
dc.contributor.authorBarausse, Giovanni-
dc.contributor.authorBortolotti, Roberto-
dc.contributor.authorSelmi, Carlo-
dc.contributor.authorParisi, Simone-
dc.contributor.authorMontecucco, Carlomaurizio-
dc.contributor.authorGonzález-Gay, Miguel Angel-
dc.identifier.citationCavagna L, Nuño L, Scirè CA, Govoni M, Longo FJ, Franceschini L, et al. Clinical Spectrum Time Course in Anti Jo-1 Positive Antisynthetase Syndrome: Results From an International Retrospective Multicenter Study. 2015 Medicine (Baltimore). Aug;94(32):e1144.es_ES
dc.identifier.issn1536-5964 (Online)es_ES
dc.identifier.issn0025-7974 (Print)es_ES
dc.description.abstractAnti Jo-1 antibodies are the main markers of the antisynthetase syndrome (ASSD), an autoimmune disease clinically characterized by the occurrence of arthritis, myositis, and interstitial lung disease (ILD). These manifestations usually co-occur (for practical purpose complete forms) in the same patient, but cases with only 1 or 2 of these findings (for practical purpose incomplete forms) have been described. In incomplete forms, the ex novo occurrence of further manifestations is possible, although with frequencies and timing not still defined. The aim of this international, multicenter, retrospective study was to characterize the clinical time course of anti Jo-1 positive ASSD in a large cohort of patients. Included patients should be anti Jo-1 positive and with at least 1 feature between arthritis, myositis, and ILD. We evaluated the differences between complete and incomplete forms, timing of clinical picture appearance and analyzed factors predicting the appearance of further manifestations in incomplete ASSD. Finally, we collected 225 patients (58 males and 167 females) with a median follow-up of 80 months. At the onset, complete ASSD were 44 and incomplete 181. Patients with incomplete ASSD had frequently only 1 of the classic triad findings (110 cases), in particular, isolated arthritis in 54 cases, isolated myositis in 28 cases, and isolated ILD in 28 cases. At the end of follow-up, complete ASSD were 113, incomplete 112. Only 5 patients had an isolated arthritis, only 5 an isolated myositis, and 15 an isolated ILD. During the follow-up, 108 patients with incomplete forms developed further manifestations. Single main feature onset was the main risk factor for the ex novo appearance of further manifestation. ILD was the prevalent ex novo manifestation (74 cases). In conclusion, ASSD is a condition that should be carefully considered in all patients presenting with arthritis, myositis, and ILD, even when isolated. The ex novo appearance of further manifestations in patients with incomplete forms is common, thus indicating the need for an adequate clinical and instrumental follow-up. Furthermore, the study clearly suggested that in ASSD multidisciplinary approach involving Rheumatology, Neurology, Pneumology, and Internal Medicine specialists is mandatory.es_ES
dc.publisherLippincott, Williams & Wilkinses_ES
dc.relation.ispartofMedicine (Baltimore)es_ES
dc.subjectAnticuerpos antinucleareses_ES
dc.subjectEstudios retrospectivoses_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Age Groups::Adultes_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Age Groups::Adult::Agedes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies::Antibodies, Antinucleares_ES
dc.subject.meshMedical Subject Headings::Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritises_ES
dc.subject.meshMedical Subject Headings::Check Tags::Femalees_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Check Tags::Malees_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Agedes_ES
dc.subject.meshMedical Subject Headings::Diseases::Musculoskeletal Diseases::Muscular Diseases::Myositises_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studieses_ES
dc.titleClinical Spectrum Time Course in Anti Jo-1 Positive Antisynthetase Syndrome: Results From an International Retrospective Multicenter Studyes_ES
dc.contributor.groupAENEAS (American, European NEtwork of Antisynthetase Syndrome) collaborative groupes_ES
dc.rights.accessRightsAcceso abiertoes_ES
dc.contributor.authoraffiliation[Cavagna,L; Caporali,L; Montecucco,C] Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foudation, Pavia, Italy. [Nuño,L] Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain. [Scire,CA] Epidemiology Unit, Italian Society for Rheumatology, Milano, Italy. [Govoni ,M; Furini,F; La Corte,R; Foschi,V] UOC Reumatologia, Azienda Ospedaliero Universitaria S. Anna, University of Ferrara, Ferrara, Italy. [Lopez Longo.FJ; Martínez-Barrio,J; Hinojosa,M] Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Franceschini,F; Airó,P; Cavazzana,I] Rheumatology Unit, University and AO Spedali Civili, Brescia, Italy. [Neri,R; Barsotti,S] Division of Rheumatology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. [Castañeda,S] Department of Rheumatology, Hospital Universitario de la Princesa, IIS Princesa, Madrid, Spain.[Sifuentes Giraldo,WA; Bachiller Corral,AJ] Department of Rheumatology, University Hospital Ramón y Cajal, Madrid, Spain. [Iannone,F] Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy. [Fusaro,E; Parisi,S] Department of Rheumatology, Città Della Salute e della Scienza, Torino, Italy. [Paolazzi,G; Barausse,G; Bortolotti,R] Rheumatology Unit, Santa Chiara Hospital, Trento, Italy. [Pellerito,R; Vitetta,R; Russo,A] Division of Rheumatology, Mauriziano Hospital, Turin, Italy. [Schwarting,A; Menke,J] Department of Internal Medicine, Rheumatology and Clinical Immunology, University Hospital Johannes-Gutenberg, Mainz, Germany. [Saketkoo,LA] Tulane University Lung Center Tulane/UMC Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans, LA, USA. [Ortego-Centeno,N] Systemic Autoimmune Diseases Unit, Hospital Clínico San Cecilio, Granada, Spain. [Quartuccio,L] Santa Maria della Misericordia Hospital, Udine, Italy. [Bartoloni,E] Clinic of Rheumatology, Department of Medical and Biological Sciences. Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy. [Specker,C] Department for Rheumatology and Clinical Immunology, St. Josef Krankenhaus, University Clinic, Essen, Germany. [Pina Murcia,T; González-Gay,MA] Division of Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, University of Cantabria, Santander, Spain. [Triantafyllias,K] ACURA Rheumatology Center, Bad Kreuznach, Germany. [Bajocchi,G] Rheumatology Unit, Department of Internal Medicine, S. Maria Hospital—IRCCS, Reggio Emilia, Italy. [Bravi,E] Rheumatology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy. [Selmi,C] Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Rozzano, Milano, Italy.es_ES
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