Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2638
Título : Characterization and risk estimate of cancer in patients with primary Sjögren syndrome
Autor : Brito-Zerón, Pilar
Kostov, Belchin
Fraile, Guadalupe
Caravia-Durán, Daniel
Maure, Brenda
Rascón, Francisco-Javier
Zamora, Mónica
Casanovas, Arnau
Lopez-Dupla, Miguel
Ripoll, Mar
Pinilla, Blanca
Fonseca, Eva
Akasbi, Miriam
de la Red, Gloria
Duarte-Millán, Miguel-Angel
Fanlo, Patricia
Guisado-Vasco, Pablo
Pérez-Alvarez, Roberto
Chamorro, Antonio J
Morcillo, César
Jiménez-Heredia, Iratxe
Sánchez-Berná, Isabel
López-Guillermo, Armando
Ramos-Casals, Manuel
Filiación: [Morcillo,C; Brito-Zerón,P] Autoimmune Diseases Unit, Department of Internal Medicine, Hospital CIMA-Sanitas, Barcelona, Spain. [Brito-Zerón;P: Sánchez-Berná,I; Ramos-Casals,M] Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Barcelona, Spain. [Kostov,B] Transversal group for research in primary care, IDIBAPS, Consorci d’Atenció Primària de Salut Barcelona Esquerre (CAPSBE), Barcelona, Spain. [Fraile,G] Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Spain. [Caravia-Durán,D] Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain. [Maure,B] Department of Internal Medicine, Complejo Hospitalario Universitario, Vigo, Spain. [Rascón,FJ] Department of Internal Medicine, Hospital Son Espases, Palma de Mallorca, Spain. [Zamora,M; Sánchez-Berná,I] Department of Internal Medicine, Hospital Virgen de las Nieves, Granada, Spain. [Casanovas,A] Department of Internal Medicine, Hospital Parc Taulí, Sabadell, Spain. [ Lopez-Dupla,M] Department of Internal Medicine, Hospital Joan XXIII, Tarragona, Spain. [Ripoll,M] Department of Internal Medicine, Hospital Infanta Sofía, Madrid, Spain. [Pinilla,B] Department of Internal Medicine, Hospital Gregorio Marañón, Madrid, Spain. [Fonseca,E] Department of Internal Medicine, Hospital de Cabueñes, Gijón, Spain. [Akasbi,M] Department of Internal Medicine, Hospital Infanta Leonor, Madrid, Spain. [de la Red,G] Department of Internal Medicine, Hospital Esperit Sant, Santa Coloma de Gramenet, Spain. [Duarte-Millán,MA] Department of Internal Medicine, Hospital de Fuenlabrada, Fuenlabrada, Spain. [Fanlo,P] Department of Internal Medicine, Hospital Virgen del Camino, Pamplona, Spain. [Guisado-Vasco,P] Department of Internal Medicine, Complejo Hospitalario Ruber Juan Bravo, Madrid, Spain. [Pérez-Alvarez,R] Department of Internal Medicine, Hospital Alvaro Cunqueiro, Vigo, Spain. [Chamorro,AJ] Department of Internal Medicine, Hospital de Salamanca, Salamanca, Spain. [ Jiménez-Heredia,i] Department of Internal Medicine, Hospital de Sagunto, Valencia, Spain. [López-Guillermo,A] Department of Hematology, ICMHO, Hospital Clinic, Barcelona, Spain. [Ramos-Casals,M] Department of Medicine, University of Barcelona, Barcelona, Spain.
Grupo de Investigación: The SS Study Group GEAS-SEMI
Palabras clave : Sjögren syndrome
Cancer
Lymphoma
Crioglobulinas
Estudios de seguimiento
Enfermedad de hodgkin
Incidencia
Labio
Linfoma de células b de la zona marginal
Gammopatía monoclonal de relevancia indeterminada
Mieloma múltiple
Pronóstico
Análisis de regresión
Síndrome de sjögren
Neoplasias gástricas
Neoplasias de la tiroides
MeSH: Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Globulins::Serum Globulins::Immunoglobulins::Paraproteins::Cryoglobulins
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Hodgkin Disease
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Stomatognathic System::Mouth::Lip
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell::Lymphoma, B-Cell, Marginal Zone
Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Blood Protein Disorders::Hypergammaglobulinemia::Monoclonal Gammopathy of Undetermined Significance
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Plasma Cell::Multiple Myeloma
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysis
Medical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Arthritis, Rheumatoid::Sjogren's Syndrome
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Stomach Neoplasms
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Thyroid Neoplasms
Fecha de publicación : 17-Apr-2017
Editorial : BioMed Central
Cita Bibliográfica: Brito-Zerón P, Kostov B, Fraile G, Caravia-Durán D, Maure B, Rascón FJ et al. Characterization and risk estimate of cancer in patients with primary Sjögren syndrome. J Hematol Oncol. 2017 Apr 17;10(1):90.
Abstract: BACKGROUND: The purpose of this study is to characterize the risk of cancer in a large cohort of patients with primary Sjögren syndrome (SjS). METHODS: We had analyzed the development of cancer in 1300 consecutive patients fulfilling the 2002 SjS classification criteria. The baseline clinical and immunological characteristics and systemic activity (ESSDAI scores) were assessed at diagnosis as predictors of cancer using Cox proportional hazards regression analysis adjusted for age at diagnosis and gender. The sex-and age-specific standardized incidence ratios (SIR) of cancer were estimated from 2012 Spanish mortality data. RESULTS: After a mean follow-up of 91 months, 127 (9.8%) patients developed 133 cancers. The most frequent type of cancer was B-cell lymphoma (including 27 MALT and 19 non-MALT B-cell lymphomas). Systemic activity at diagnosis of primary SjS correlated with the risk of hematological neoplasia and cryoglobulins with a high risk of either B-cell or non-B-cell lymphoma subtypes. Patients with cytopenias had a high risk of non-MALT B-cell and non-B-cell cancer, while those with low C3 levels had a high risk of MALT lymphomas and those with monoclonal gammopathy and low C4 levels had a high risk of non-MALT lymphomas. The estimated SIR for solid cancer was 1.13 and 11.02 for hematological cancer. SIRs for specific cancers were 36.17 for multiple myeloma and immunoproliferative diseases, 19.41 for Hodgkin lymphoma, 6.04 for other non-Hodgkin lymphomas, 5.17 for thyroid cancer, 4.81 for cancers of the lip and oral cavity, and 2.53 for stomach cancer. CONCLUSIONS: One third of cancers developed by patients with primary SjS are B-cell lymphomas. The prognostic factors identified at SjS diagnosis differed according to the subtype of B-cell lymphoma developed. Primary SjS is also associated with the development of some non-hematological cancers (thyroid, oral cavity, and stomach).
Descripción : The members of the SS Study Group, Autoimmune Diseases Study Group (GEAS), Spanish Society of Internal Medicine (SEMI) involved in this project have been: M. Ramos-Casals (Coordinator), P. Brito-Zerón, S. Retamozo, A. Bové, H. Gheitasi,I. Sánchez-Berná, J. Gratacós (Sjögren Syndrome Research Group-AGAUR, Laboratory of Autoimmune Diseases Josep Font, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Barcelona); G. Fraile, J. Nava-Mateos (Department of Internal Medicine, Hospital Ramón y Cajal, Madrid); B.Díaz-López, D. Caravia-Duran, A. García-Pérez (Department of Internal Medicine, Hospital Universitario Central de Asturias, Oviedo); A.Casanovas, M.L. Morera-Morales, T.E. Junco-Russeau (Department of Internal Medicine, Hospital Parc Taulí, Sabadell); F.J. Rascón, L. Pallarés (Department of Internal Medicine, Hospital Son Espases, Palma de Mallorca); R. Pérez-Alvarez, M. Perez-de-Lis (Department of Internal Medicine, Hospital Alvaro Cunqueiro); M. Ripoll, C. Moreno-delaSantaGarcía (Department of Internal Medicine, Hospital Infanta Sofía, Madrid); B. Pinilla, C. López-GónzalezCobos (Department of Internal Medicine, Hospital Gregorio Marañón, Madrid); M. Akasbi, I. García-Sanchez (Department of Internal Medicine, Hospital Infanta Leonor, Madrid); B.Maure (Department of Internal Medicine, Complejo Hospitalario Universitario, Vigo); E. Fonseca (Department of Internal Medicine, Hospital de Cabueñes, Gijón); M.A. Duarte-Millán, J. Canora (Department of Internal Medicine, Hospital Universitario de Fuenlabrada, Madrid); G de la Red, N. Msabri (Department of Internal Medicine, Hospital Esperit Sant, Santa Coloma de Gramenet, Barcelona); A.J. Chamorro, S. Rodríguez Rodríguez (Department of Internal Medicine, Complejo Hospitalario de Salamanca, Salamanca); I. Jiménez-Heredia (Department of Internal Medicine, Hospital de Sagunt, Valencia, Spain); M.A. López-Dupla, J.A.Porras-Ledantes, B. Villar-Navas, J. Ramos-Rodriguez (Department of Internal Medicine, Hospital Joan XXIII, Tarragona); P. Brito-Zerón, C. Morcillo (Department of Internal Medicine, Hospital CIMA-Sanitas, Barcelona); M. Zamora, I. Sánchez-Berná (Department of Internal Medicine, Hospital Virgen de las Nieves, Granada); P. Fanlo (Department of Internal Medicine, Hospital Virgen del Camino, Pamplona); P. Guisado-Vasco (Department of Internal Medicine, Complejo Hospitalario Ruber Juan Bravo, Madrid); B. Kostov, A. Sisó-Almirall (Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, CAPSE, Barcelona, Spain).
URI: http://hdl.handle.net/10668/2638
Versión del editor : https://jhoonline.biomedcentral.com/articles/10.1186/s13045-017-0464-5#Abs1
DOI: 10.1186/s13045-017-0464-5
ISSN : 1756-8722 (Online)
Appears in Collections:01- Artículos - Complejo Hospitalario Universitario de Granada

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