Please use this identifier to cite or link to this item:
http://hdl.handle.net/10668/2644
Title: | SNPs in bone-related miRNAs are associated with the osteoporotic phenotype |
Authors: | De-Ugarte, Laura Caro-Molina, Enrique Rodríguez-Sanz, Maria García-Pérez, Miguel Angel Olmos, José M Sosa-Henríquez, Manuel Pérez-Cano, Ramón Gómez-Alonso, Carlos Del Rio, Luis Mateo-Agudo, Jesús Blázquez-Cabrera, José Antonio González-Macías, Jesús Del Pino-Montes, Javier Muñoz-Torres, Manuel Diaz-Curiel, Manuel Malouf, Jorge Cano, Antonio Pérez-Castrillon, José Luis Nogues, Xavier Garcia-Giralt, Natalia Diez-Perez, Adolfo |
metadata.dc.contributor.authoraffiliation: | [De-Ugarte,L; Caro-Molina,E; Rodríguez-Sanz,M; Nogues,X; Garcia-Giralt,N; Diez-Perez,A] IMIM (Hospital del Mar Medical Research Institute), Universitat Autònoma de Barcelona, CIBERFES, RETICEF (ISCIII), Barcelona, Spain. [García-Pérez,MA] Department of Genetics and Institute of Health Research INCLIVA, University of Valencia, Valencia, Spain. [Olmos,JM] Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL/Hospital de Torrelavega, Universidad de Cantabria. RETICEF, Santander, Spain. [Sosa-Henríquez,M] Unidad Metabólica Ósea, Hospital Universitario Insular, Universidad de Las Palmas de Gran Canaria, Canarias, Spain. [Pérez-Cano,R] Departamento de Medicina (USE), UGC Medicina Interna, Hospital Universitario Virgen Macarena, Seville, Spain. [ Gómez-Alonso,C] Servicio de Metabolismo Óseo y Mineral, Hospital Universitario Central de Asturias, Oviedo, Spain. [Del Rio,L] CETIR Grup Mèdic, RETICEF, Barcelona, Spain. [Mateo-Agudo,J] Servicio COT, Hospital Universitario Miguel Servet, Zaragoza, Spain. [Blázquez-Cabrera,JA] Servicio de Medicina Interna, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. [González-Macías,J] Departamento de Medicina Interna, H. Marqués de Valdecilla, Universidad de Cantabria, IDIVAL, RETICEF, Santander, Spain. [del Pino-Montes,J] Servicio de Reumatología. Hospital Universitario de Salamanca, RETICEF (ISCIII), IBSAL (Biomedical Research Institute of Salamanca), Salamanca, Spain. [Muñoz-Torres,M] UGC Endocrinologia y Nutrición. Hospital Universitario San Cecilio. Granada, RETICEF, Ibs, Granada, Spain. [Diaz-Curiel,M] Unidad de Enfermedades Metabólicas Óseas. Servicio de Medicina Interna. Fundacion Jimenez Diaz, Madrid, Spain. [Malouf,J] Hospital de la Santa Creu I Sant Pau. Institut d’Investigació Biomèdica Sant Pau, Barcelona, Spain. [Cano,A] Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, INCLIVA, Valencia, Spain. [Pérez-Castrillon,JL] Hospital Universitario Río Hortega, Valladolid, Spain. |
Keywords: | Alelos;Densidad ósea;Enfermedades óseas;Cuello femoral;Fracturas de cadera;Genotipo;Humanos;MicroARNs;Osteoblastos;Fracturas osteoporóticas;Fenotipo;Polimorfismo de nucleótido simple |
metadata.dc.subject.mesh: | Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleles Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Density Medical Subject Headings::Diseases::Musculoskeletal Diseases::Bone Diseases Cancellous Bone Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur::Femur Neck Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype Medical Subject Headings::Diseases::Wounds and Injuries::Fractures, Bone::Hip Fractures Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Osteoblasts Medical Subject Headings::Diseases::Wounds and Injuries::Fractures, Bone::Osteoporotic Fractures Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Cancellous Bone |
Issue Date: | 31-Mar-2017 |
Publisher: | Nature Publishing Group |
Citation: | De-Ugarte L, Caro-Molina E, Rodríguez-Sanz M, García-Pérez MA, Olmos JM, Sosa-Henríquez M et al.SNPs in bone-related miRNAs are associated with the osteoporotic phenotype. Sci Rep. 2017 Mar 31;7(1):516. |
Abstract: | Biogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotypic variability. This study aims to identify single nucleotide polymorphisms (SNPs) affecting the expression levels of bone-related mature microRNAs and thus, triggering an osteoporotic phenotype. An association analysis of SNPs located in pri-miRNA sequences with bone mineral density (BMD) was performed in the OSTEOMED2 cohort (n = 2183). Functional studies were performed for assessing the role of BMD-associated miRNAs in bone cells. Two SNPs, rs6430498 in the miR-3679 and rs12512664 in the miR-4274, were significantly associated with femoral neck BMD. Further, we measured these BMD-associated microRNAs in trabecular bone from osteoporotic hip fractures comparing to non-osteoporotic bone by qPCR. Both microRNAs were found overexpressed in fractured bone. Increased matrix mineralization was observed after miR-3679-3p inhibition in human osteoblastic cells. Finally, genotypes of rs6430498 and rs12512664 were correlated with expression levels of miR-3679 and miR-4274, respectively, in osteoblasts. In both cases, the allele that generated higher microRNA expression levels was associated with lower BMD values. In conclusion, two osteoblast-expressed microRNAs, miR-3679 and miR-4274, were associated with BMD; their overexpression could contribute to the osteoporotic phenotype. These findings open new areas for the study of bone disorders. |
URI: | http://hdl.handle.net/10668/2644 |
metadata.dc.relation.publisherversion: | https://www.nature.com/articles/s41598-017-00641-7 |
metadata.dc.identifier.doi: | 10.1038/s41598-017-00641-7 |
ISSN: | 2045-2322 (Online) |
Appears in Collections: | 01- Artículos - Complejo Hospitalario Universitario de Granada 01- Artículos - Hospital Virgen Macarena 01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada |
Files in This Item:
File | Description | Size | Format | |
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DeUGarte_SNPsInBonerelatedMiRNAs.pdf | Artículo publicado | 1,51 MB | Adobe PDF | View/Open |
DeUGarte_SNPsInBonerelatedMiRNAsSupp.pdf | Material suplementario | 329,39 kB | Adobe PDF | View/Open |
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