Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2649
Título : Role of capsule endoscopy in suspected celiac disease: A European multi-centre study
Autor : Luján-Sanchis, M
Pérez-Cuadrado-Robles, E
García-Lledó, J
Juanmartiñena Fernández, JF
Elli, L
Jiménez-García, VA
Egea-Valenzuela, J
Valle-Muñoz, J
Carretero-Ribón, C
Fernández-Urién-Sainz, I
López-Higueras, A
Alonso-Lázaro, N
Sanjuan-Acosta, M
Sánchez-Ceballos, F
Rosa, B
González-Vázquez, S
Branchi, F
Ruano-Díaz, I
Prieto-De-Frías, C
Pons-Beltrán, V
Borque-Barrera, P
González-Suárez, B
Xavier, S
Argüelles-Arias, F
Herrerías-Gutiérrez, JM
Pérez-Cuadrado-Martínez, E
Sempere-García-Argüelles, J
Filiación: [Luján-Sanchis,M; Sempere-García-Argüelles,J] Digestive Diseases Unit, General University Hospital of Valencia, Valencia, Spain. [Pérez-Cuadrado-Robles,E; López-Higueras,A; Pérez-Cuadrado-Martínez,E] Small Bowel Unit, Hospital Morales Meseguer, Murcia, Spain. [Sánchez-Ceballos,F] Digestive Diseases Unit, General University Gregorio Marañón, Madrid, Spain. [Juanmartiñena Fernández JF; Fernández-Urién-Sainz,I] Unit of Gastroenterology and Endoscopy, Complejo Hospitalario de Navarra, Pamplona, Spain. [Elli,L; Branchi,F] Center for Prevention and Diagnosis of Celiac Disease, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. [Jiménez-García,VA; Argüelles-Arias,F; Herrerías-Gutiérrez,JM] Unit of Gastroenterology and Endoscopy, University Hospital Virgen Macarena, Sevilla, Spain. [Egea-Valenzuela,J] Gastroenterology Department, Hospital Virgen de la Arrixaca, Murcia, Spain. [Valle-Muñoz,J; Ruano-Díaz,I] Department of Gastroenterology, Complejo Hospitalario de Toledo, Toledo, Spain. [Carretero-Ribón,C; González-Vázquez,S; Prieto-De-Frías,C] Department of Gastroenterology, University of Navarra Clinic, Pamplona, Spain. [Alonso-Lázaro,N; Pons-Beltrán,V] Endoscopy Digestive Unit, Digestive Diseases Area, Universitari i Politècnic la Fe Hospital, Valencia, Spain. [Sanjuan-Acosta,M; Borque-Barrera,P] Digestive Diseases Unit, University Hospital Nuestra Señora de Candelaria, Tenerife, Spain. [Sánchez-Ceballos,F] Digestive Diseases Unit, Clinical Hospital San Carlos, Madrid, Spain. [Rosa,B; Xavier,S] Digestive Diseases Unit, Hospital da Senhora da Oliveira - Guimarães, Cutileiros, Portugal. [González-Suárez,B] Endoscopy Digestive Unit, Hospital Clinic de Barcelona, Barcelona, Spain.
Palabras clave : Anti-transglutaminase antibodies
Capsule endoscopy
Celiac disease
Gluten-free diet
Non-celiac gluten sensitivity
Atrofia
Endoscopía capsular
Enfermedad celíaca
Enfermedad de Crohn
MeSH: Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathological Conditions, Anatomical::Atrophy
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Surgical::Endoscopy::Endoscopy, Digestive System::Endoscopy, Gastrointestinal::Capsule Endoscopy
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Malabsorption Syndromes::Celiac Disease
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases::Crohn Disease
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnosis, Differential
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet
Medical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestine, Small::Duodenum
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Digestive System::Endoscopy, Digestive System::Endoscopy, Gastrointestinal::Gastroscopy
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases
Medical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestine, Small::Jejunum
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies
Fecha de publicación : 28-Jan-2017
Editorial : Baishideng Publishing Group
Cita Bibliográfica: Luján-Sanchis M, Pérez-Cuadrado-Robles E, García-Lledó J, Juanmartiñena Fernández JF, Elli L, Jiménez-García V A, Egea-Valenzuela J, et al. Role of capsule endoscopy in suspected celiac disease: A European multi-centre study. World Journal of Gastroenterology. 2017;23(4):703-711
Abstract: AIM To analyze the diagnostic yield (DY), therapeutic impact (TI) and safety of capsule endoscopy (CE). METHODS This is a multi-centre, observational, analytical, retrospective study. A total of 163 patients with suspicion of celiac disease (CD) (mean age = 46.4 ± 17.3 years, 68.1% women) who underwent CE from 2003 to 2015 were included. Patients were divided into four groups: seronegative CD with atrophy (Group- ?, n = 19), seropositive CD without atrophy (Group- ?, n = 39), contraindication to gastroscopy (Group-?, n = 6), seronegative CD without atrophy, but with a compatible context (Group-?, n = 99). DY, TI and the safety of CE were analysed. RESULTS The overall DY was 54% and the final diagnosis was villous atrophy (n = 65, 39.9%), complicated CD (n = 12, 7.4%) and other enteropathies (n = 11, 6.8%; 8 Crohn's). DY for groups ? to ? was 73.7%, 69.2%, 50% and 44.4%, respectively. Atrophy was located in duodenum in 24 cases (36.9%), diffuse in 19 (29.2%), jejunal in 11 (16.9%), and patchy in 10 cases (15.4%). Factors associated with a greater DY were positive serology (68.3% vs 49.2%, P = 0.034) and older age (P = 0.008). On the other hand, neither sex nor clinical presentation, family background, positive histology or HLA status were associated with DY. CE results changed the therapeutic approach in 71.8% of the cases. Atrophy was associated with a greater TI (92.3% vs 45.3%, P < 0.001) and 81.9% of the patients responded to diet. There was one case of capsule retention (0.6%). Agreement between CE findings and subsequent histology was 100% for diagnosing normal/other conditions, 70% for suspected CD and 50% for complicated CD. CONCLUSION CE has a high DY in cases of suspicion of CD and it leads to changes in the clinical course of the disease. CE is safe procedure with a high degree of concordance with histology and it helps in the differential diagnosis of CD. © The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
URI: http://hdl.handle.net/10668/2649
Versión del editor : http://www.wjgnet.com/1007-9327/full/v23/i4/703.htm
DOI: 10.3748/wjg.v23.i4.703
ISSN : 1007-9327 (Print)
2219-2840 (Online)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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