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http://hdl.handle.net/10668/2669
Title: | Effects of Intermittent Alcohol Exposure on Emotion and Cognition: A Potential Role for the Endogenous Cannabinoid System and Neuroinflammation |
Authors: | Sanchez-Marin, Laura Pavon, Francisco J Decara, Juan Suarez, Juan Gavito, Ana Castilla-Ortega, Estela Rodriguez de Fonseca, Fernando Serrano, Antonia |
metadata.dc.contributor.authoraffiliation: | Unidad de Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga, Hospital Regional Universitario de Malaga, Universidad de Malaga, Malaga, Spain. |
Keywords: | Rats;Intermittent alcohol;Adolescence;Endocannabinoid system;Neuroinflammation;Anxiety;Brain;Recognition memory;Adolescente;Intoxicación alcohólica;Aloinjertos;Amígdala del cerebelo;Animales;Ansiedad;Conducta adictiva;Borrachera;Cognición;Hormona liberadora de corticotropina;Ciclooxigenasa 2;Endocannabinoides;Etanol;Proteína ácida fibrilar de la glía;Hipocampo;Humanos;Lipoproteína lipasa;Plasticidad neuronal;Neuropéptido Y;PPAR alfa;Fosfatidiletanolaminas;Fosfolipasa D;Corteza prefrontal;ARN mensajero;Ratas wistar;Receptor cannabinoide CB1;Receptor cannabinoide CB2;Receptor Toll-Like 4;Factor de necrosis tumoral alfa;Consumo de alcohol en menores |
metadata.dc.subject.mesh: | Medical Subject Headings::Persons::Persons::Age Groups::Adolescent Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcoholic Intoxication Medical Subject Headings::Anatomy::Body Regions::Transplants::Allografts Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Basal Ganglia::Amygdala Medical Subject Headings::Organisms::Eukaryota::Animals Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Impulsive Behavior::Compulsive Behavior::Behavior, Addictive Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking::Binge Drinking Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Hypothalamic Hormones::Pituitary Hormone-Releasing Hormones::Corticotropin-Releasing Hormone Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Multienzyme Complexes::Prostaglandin-Endoperoxide Synthases::Cyclooxygenase 2 Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Endocannabinoids Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Intermediate Filament Proteins::Glial Fibrillary Acidic Protein Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Cerebral Cortex::Hippocampus Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Carboxylic Ester Hydrolases::Lipoprotein Lipase Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Neuronal Plasticity Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Neuropeptides::Neuropeptide Y Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Receptors, Cytoplasmic and Nuclear::Peroxisome Proliferator-Activated Receptors::PPAR alpha Medical Subject Headings::Chemicals and Drugs::Lipids::Membrane Lipids::Phospholipids::Glycerophosphates::Phosphatidic Acids::Glycerophospholipids::Phosphatidylethanolamines Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Diester Hydrolases::Phospholipases::Phospholipase D Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Cerebral Cortex::Frontal Lobe::Prefrontal Cortex Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid::Receptor, Cannabinoid, CB1 Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid::Receptor, Cannabinoid, CB2 Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Pattern Recognition::Toll-Like Receptors::Toll-Like Receptor 4 Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alpha Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Adolescent Behavior::Underage Drinking |
Issue Date: | 7-Feb-2017 |
Publisher: | Frontiers Media |
Citation: | Sanchez-Marin L, Pavon FJ, Decara J, Suarez J, Gavito A, Castilla-Ortega E, et al. Effects of Intermittent Alcohol Exposure on Emotion and Cognition: A Potential Role for the Endogenous Cannabinoid System and Neuroinflammation. Front behav neurisc. 2017; 11:15 |
Abstract: | Intermittent alcohol exposure is a common pattern of adolescent alcohol use that can lead to binge drinking episodes. Alcohol use is known to modulate the endocannabinoid system (ECS), which is involved in neuronal communication, neuroplasticity, neuroinflammation and behavior. Adolescent male Wistar rats were exposed to 4-week intermittent alcohol intoxication (3 g/kg injections for 4 days/week) or saline (N = 12 per group). After alcohol deprivation, adult rats were assessed for emotionality and cognition and the gene expression of the ECS and other factors related to behavior and neuroinflammation was examined in the brain. Alcohol-exposed rats exhibited anxiogenic-like responses and impaired recognition memory but no motor alterations. There were brain region-dependent changes in the mRNA levels of the ECS and molecular signals compared with control rats. Thus, overall, alcohol-exposed rats expressed higher mRNA levels of endocannabinoid synthetic enzymes (N-acyl-phosphatidylethanolamine phospholipase D and diacylglycerol lipases) in the medial-prefrontal cortex (mPFC) but lower mRNA levels in the amygdala. Furthermore, we observed lower mRNA levels of receptors CB1 CB2 and peroxisome proliferator-activated receptor-α in the striatum. Regarding neuropeptide signaling, alcohol-exposed rats displayed lower mRNA levels of the neuropeptide Y signaling, particularly NPY receptor-2, in the amygdala and hippocampus and higher mRNA levels of corticotropin-releasing factor in the hippocampus. Additionally, we observed changes of several neuroinflammation-related factors. Whereas, the mRNA levels of toll-like receptor-4, tumor necrosis factor-α, cyclooxygenase-2 and glial fibrillary acidic protein were significantly increased in the mPFC, the mRNA levels of cyclooxygenase-2 and glial fibrillary acidic protein were decreased in the striatum and hippocampus. However, nuclear factor-κβ mRNA levels were lower in the mPFC and striatum and allograft inflammatory factor-1 levels were differentially expressed in the amygdala and hippocampus. In conclusion, rats exposed to adolescent intermittent alcohol displayed anxiety-like behavior and cognitive deficits in adulthood and these alterations were accompanied by brain region-dependent changes in the gene expression of the ECS and other signals associated with neuroinflammation and behavior. An intermittent adolescent alcohol exposure has behavioral and molecular consequences in the adult brain, which might be linked to higher vulnerability to addictive behaviors and psychopathologies. |
URI: | http://hdl.handle.net/10668/2669 |
metadata.dc.relation.publisherversion: | http://journal.frontiersin.org/article/10.3389/fnbeh.2017.00015/full |
metadata.dc.identifier.doi: | 10.3389/fnbeh.2017.00015 |
ISSN: | 1662-5153 (Online) |
Appears in Collections: | 01- Artículos - Hospital Regional de Málaga 01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga |
Files in This Item:
File | Description | Size | Format | |
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SanchezMarinL_EffectsOfIntermittent.pdf | Artículo publicado | 1,66 MB | Adobe PDF | View/Open |
SanchezMarinL_EffectsOfIntermittentTable1.docx | Tabla 1 | 23,16 kB | Microsoft Word XML | View/Open |
SanchezMarinL_EffectsOfIntermittentTable2.docx | Tabla 2 | 20,65 kB | Microsoft Word XML | View/Open |
SanchezMarinL_EffectsOfIntermittentTable3.docx | Tabla 3 | 22,76 kB | Microsoft Word XML | View/Open |
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