Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2675
Título : BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas
Autor : Ibáñez-Costa, Alejandro
López-Sánchez, Laura M
Gahete, Manuel D
Rivero-Cortés, Esther
Vázquez-Borrego, Mari C
Gálvez, María A
de la Riva, Andrés
Venegas-Moreno, Eva
Jiménez-Reina, Luis
Moreno-Carazo, Alberto
Tinahones, Francisco J
Maraver-Selfa, Silvia
Japón, Miguel A
García-Arnés, Juan A
Soto-Moreno, Alfonso
Webb, Susan M
Kineman, Rhonda D
Culler, Michael D
Castaño, Justo P
Luque, Raúl M
Filiación: [Ibáñez-Costa,A; López-Sánchez,LM; Gahete,MD; Rivero-Cortés,E; Vázquez-Borrego,MC; Gálvez,MA; de la Riva,A; Castaño,JP; Luque,RM] Maimonides Institute of Biomedical Research of Cordoba (IMIBIC); Cordoba, Spain. [Ibáñez-Cortes,A; Gahete,MD; Rivero-Cortés,E; Vázquez-Borrego,MC; Castaño,JP; Luque, RM] Department of Cell Biology, Physiology and Immunology, University of Cordoba; Cordoba, Spain. [Ibáñez-Costa,A; López-Sánchez,LM; Gahete,MD; Rivero-Cortés,E; Vázquez-Borrego,MC; Gálvez,MA; de la Riva,A; Castaño,JP; Luque,RM] Hospital Universitario Reina Sofía (HURS); Cordoba, Spain. [Ibáñez-Costa,A; Gahete,MD; Rivero-Cortés,E; Vázquez-Borrego,MC; Castaño,JP; Luque,RM] CIBER de la Fisiopatología de la Obesidad y Nutrición (CIBERobn); Cordoba, Spain. Campus de Excelencia Internacional Agroalimentario (ceiA3); Cordoba, Spain. [Gálvez,MA] Service of Endocrinology and Nutrition, IMIBIC, HURS, Cordoba, Spain. [de la Riva,A] Service of Neurosurgery, HURS, Cordoba, Spain. [Venegas-Moreno,E; Soto-Moreno,A] Metabolism and Nutrition Unit, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Seville, Spain. [Jiménez-Reina,L] Department of Morphological Sciences, University of Cordoba, Cordoba, Spain. [Moreno-Carazo,A] Endocrinology and Nutrition Unit, Complejo Hospitalario de Jaén, Jaén, Spain. [Maraver-Selfa,S] Service of Endocrinology and Nutrition, Hospital Clínico Universitario Virgen de la Victoria, Málaga, Spain. [Japón,MA] Department of Pathology, Hospital Universitario Virgen del Rocío, Seville, Spain. [García-Arnés,JA] Department of Endocrinology and Nutrition, Carlos Haya Hospital, Málaga, Spain. [Webb-SM] Department of Endocrinology, Hospital Sant Pau, Centre for Biomedical Research on Rare Diseases (Centro de Investigación Biomédica en Red de Enfermedades Raras Unit 747) Autonomous University of Barcelona; Barcelona Spain. [Kineman,RD] Department of Medicine, University of Illinois at Chicago, Jesse Brown Veterans Affairs Medical Center, Research and Development Division, Chicago, Illinois, USA. [Culler,MD] IPSEN Bioscience, Cambridge, Massachusetts, USA.
Palabras clave : Adenoma hipofisario secretor de ACTH
Adenoma
Apoptosis
Supervivencia celular
Dopamina
Humanos
Hormonas hipofisarias
Neoplasias hipofisarias
Primates
Receptores dopaminérgicos
Receptores de somatostatina
Somatostatina
MeSH: Medical Subject Headings::Diseases::Endocrine System Diseases::Endocrine Gland Neoplasms::Pituitary Neoplasms::ACTH-Secreting Pituitary Adenoma
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Adenoma
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Survival
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Catecholamines::Dopamine
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones
Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary Neoplasms
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Neurotransmitter::Receptors, Biogenic Amine::Receptors, Catecholamine::Receptors, Dopamine
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Neurotransmitter::Receptors, Neuropeptide::Receptors, Somatostatin
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Hypothalamic Hormones::Pituitary Hormone Release Inhibiting Hormones::Somatostatin
Fecha de publicación : 9-Feb-2017
Editorial : Nature Publishing Group
Cita Bibliográfica: Ibáñez-Costa A, López-Sánchez LM, Gahete MD, Rivero-Cortés E, Vázquez-Borrego MC, Gálvez MA, et al. BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas. Sci Rep. 2017; Feb 9;7:42002
Abstract: Chimeric somatostatin/dopamine compounds such as BIM-23A760, an sst2/sst5/D2 receptors-agonist, have emerged as promising new approaches to treat pituitary adenomas. However, information on direct in vitro effects of BIM-23A760 in normal and tumoral pituitaries remains incomplete. The objective of this study was to analyze BIM-23A760 effects on functional parameters (Ca(2+) signaling, hormone expression/secretion, cell viability and apoptosis) in pituitary adenomas (n = 74), and to compare with the responses of normal primate and human pituitaries (n = 3-5). Primate and human normal pituitaries exhibited similar sst2/sst5/D2 expression patterns, wherein BIM-23A760 inhibited the expression/secretion of several pituitary hormones (specially GH/PRL), which was accompanied by increased sst2/sst5/D2 expression in primates and decreased Ca(2+) concentration in human cells. In tumoral pituitaries, BIM-23A760 also inhibited Ca(2+) concentration, hormone secretion/expression and proliferation. However, BIM-23A760 elicited stimulatory effects in a subset of GHomas, ACTHomas and NFPAs in terms of Ca(2+) signaling and/or hormone secretion, which was associated with the relative somatostatin/dopamine-receptors levels, especially sst5 and sst5TMD4. The chimeric sst2/sst5/D2 compound BIM-23A760 affects multiple, clinically relevant parameters on pituitary adenomas and may represent a valuable therapeutic tool. The relative ssts/D2 expression profile, particularly sst5 and/or sst5TMD4 levels, might represent useful molecular markers to predict the ultimate response of pituitary adenomas to BIM-23A760.
URI: http://hdl.handle.net/10668/2675
Versión del editor : https://www.nature.com/articles/srep42002
DOI: 10.1038/srep42002
ISSN : 2045-2322 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria
01- Artículos - Complejo Hospitalario de Jaén
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla
01- Artículos - Hospital Virgen del Rocío
01- Artículos - Hospital Reina Sofía
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba
01- Artículos - Hospital Regional de Málaga

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