Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2682
Title: Increase in CD8+CD158a+ T Cells in Kidney Graft Blood is Associated with Better Renal Function
Authors: Caballero, Abelardo
Palma, Eulalia
Ruiz-Esteban, Pedro
Sola, Eugenia
López, Verónica
Fuentes, Laura
Rudas, Edisson
Perea, Lara
Hernández, Domingo
metadata.dc.contributor.authoraffiliation: [Caballero,A] Department of Immunology, Carlos Haya Regional University Hospital, Institute of Biomedical Research in Malaga (IBIMA), University of Malaga, Malaga, Spain. [Palma,E; Ruiz-Esteban,P; Sola,E; López,V; Fuentes,L; Rudas,E; Perea, L; Hernández,D] Department of Nephrology, Carlos Haya Regional University Hospital, Institute of Biomedical Research in Malaga (IBIMA), University of Malaga, Malaga, Spain.
Keywords: Biopsy, fine-needle;Peripheral blood stem cell transplantation;Receptors, KIR;Adulto;Anciano;Femenino;Citometría de flujo;Humanos;Riñón;Pruebas de función renal;Trasplante de riñón;Estudios longitudinales;Masculino;Mediana edad;Periodo posoperatorio;Factores de tiempo;Linfocitos T CD8-positivos
metadata.dc.subject.mesh: Medical Subject Headings::Persons::Persons::Age Groups::Adult
Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cell Separation::Flow Cytometry
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Urogenital System::Urinary Tract::Kidney
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Urological::Kidney Function Tests
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Renal Replacement Therapy::Kidney Transplantation
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Services::Patient Care::Perioperative Period::Postoperative Period
Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Time::Time Factors
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::CD8-Positive T-Lymphocytes
Issue Date: 24-Jan-2017
Publisher: Springer Verlag
Citation: Caballero A, Palma E, Ruiz-Esteban P, Sola E, López V, Fuentes L, et al. Increase in CD8+CD158a+ T Cells in Kidney Graft Blood is Associated with Better Renal Function. Ann Transplant. 2017; 24;22:35-41.
Abstract: BACKGROUND Studies of liver and heart transplant patients have shown a gradual reconstruction of the CD8 KIR2D+ T cell subpopulations, measured in peripheral blood (PB), associated with better graft acceptance. The kinetics of these populations in kidney transplants, however, is still poorly understood, especially given the lack of studies of blood samples from the kidney graft. MATERIAL AND METHODS Flow cytometry was used to measure CD8+CD158a/b/e T cells in 69 kidney transplant patients who had stable renal function during follow-up. Measurements were made at 3, 6, and 12 months post-transplantation in graft capillary blood extracted by fine needle aspiration puncture (FNAP) and in PB. RESULTS No progressive increase was found in the PB subpopulations. However, the CD8+CD158a+ subsets increased significantly at 12 months in the graft blood versus the PB samples (3.91±4.59 vs. 2.84±4.71; p=0.021). The ratio of the percentage of CD8+CD158a+ cells in graft blood compared to PB at 12 months was associated with better renal function in those patients with a ratio ≥3 (66.6±14.53 vs. 55.7±21.6; p=0.032). CONCLUSIONS An increased ratio of CD8+CD158a+ cells, measured by flow cytometry, between graft blood and PB was associated with improved renal function.
URI: http://hdl.handle.net/10668/2682
metadata.dc.relation.publisherversion: http://www.annalsoftransplantation.com/download/index/idArt/900680
ISSN: 1425-9524 (Print)
2329-0358 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

Files in This Item:
File Description SizeFormat 
CaballeroA_IncreaseInCD8.pdfArtículo publicado227,61 kBAdobe PDFView/Open


This item is protected by original copyright



This item is licensed under a Creative Commons License Creative Commons