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Title: Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity
Authors: García-Marchena, Nuria
Araos, Pedro Fernando
Barrios, Vicente
Sánchez-Marín, Laura
Chowen, Julie A
Pedraz, María
Castilla-Ortega, Estela
Romero-Sanchiz, Pablo
Ponce, Guillermo
Gavito, Ana L
Decara, Juan
Silva, Daniel
Torrens, Marta
Argente, Jesús
Rubio, Gabriel
Serrano, Antonia
Rodríguez de Fonseca, Fernando
Pavón, Francisco Javier
metadata.dc.contributor.authoraffiliation: [García-Marchena,N; Araos,PF; Sánchez-Marín,L; Pedraz,M; Castilla-Ortega,E; Romero-Sanchiz,P; Gavito,AL; Decara,J; Serano,A; Rodríguez de Fonseca,F; Pavón,FJ] Unidad Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain. [García-Marchena,N; Silva,D; Rodríguez de Fonseca,F] Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain. [Barrios,V; Chowen,JA; Argente,J] Department of Endocrinology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain. Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain. CIBER Fisiopatología de la obesidad y nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain. [Ponce,G] Servicio de Psiquiatría, Hospital Universitario 12 de Octubre, Madrid, Spain, [Torrens,M] Institut de Neuropsiquiatria i Addiccions (INAD), Barcelona, Spain. Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Spain,. Department of Psychiatry, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
Keywords: Chemokine;Alcohol use disorder;Psychiatric comorbidity;Outpatient setting;PRISM;Eotaxin;Sex;Etanol;Femenino;Voluntarios sanos;Humanos;Hígado;Masculino;Trastornos del humor;Pacientes ambulatorios;Fenotipo;Prevalencia;Psiquiatría;Ratas wistar;Células del estroma;Trastornos relacionados con sustancias;gamma-glutamiltransferasa;Trastornos relacionados con alcohol;Aspartato aminotransferasas;Conducta adictiva;Quimiocina CCL11;Quimiocina CX3CL1;Quimiocina CXCL12;Comorbilidad
metadata.dc.subject.mesh: Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Alcohol-Related Disorders
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Nitrogenous Group Transferases::Transaminases::Aspartate Aminotransferases
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Impulsive Behavior::Compulsive Behavior::Behavior, Addictive
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Chemotactic Factors::Chemokines::Chemokines, CC::Chemokine CCL11
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Chemotactic Factors::Chemokines::Chemokines, CX3C::Chemokine CX3CL1
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Chemotactic Factors::Chemokines::Chemokines, CXC::Chemokine CXCL12
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Comorbidity
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanol
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Persons::Persons::Volunteers::Healthy Volunteers
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Digestive System::Liver
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Mood Disorders
Medical Subject Headings::Persons::Persons::Patients::Outpatients
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype
Medical Subject Headings::Health Care::Population Characteristics::Demography::Vital Statistics::Morbidity::Prevalence
Medical Subject Headings::Psychiatry and Psychology::Behavioral Disciplines and Activities::Behavioral Sciences::Psychiatry
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar
Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Stromal Cells
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::Aminoacyltransferases::gamma-Glutamyltransferase
Issue Date: 18-Jan-2017
Publisher: Frontiers Media
Citation: García-Marchena N, Araos PF, Barrios V, Sánchez-Marín L, Chowen JA, Pedraz M, et al. Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity. Front Psychiatry. 2017; 18;7:214.
Abstract: Recent studies have linked changes in peripheral chemokine concentrations to the presence of both addictive behaviors and psychiatric disorders. The present study further explore this link by analyzing the potential association of psychiatry comorbidity with alterations in the concentrations of circulating plasma chemokine in patients of both sexes diagnosed with alcohol use disorders (AUD). To this end, 85 abstinent subjects with AUD from an outpatient setting and 55 healthy subjects were evaluated for substance and mental disorders. Plasma samples were obtained to quantify chemokine concentrations [C-C motif (CC), C-X-C motif (CXC), and C-X3-C motif (CX3C) chemokines]. Abstinent AUD patients displayed a high prevalence of comorbid mental disorders (72%) and other substance use disorders (45%). Plasma concentrations of chemokines CXCL12/stromal cell-derived factor-1 (p < 0.001) and CX3CL1/fractalkine (p < 0.05) were lower in AUD patients compared to controls, whereas CCL11/eotaxin-1 concentrations were strongly decreased in female AUD patients (p < 0.001). In the alcohol group, CXCL8 concentrations were increased in patients with liver and pancreas diseases and there was a significant correlation to aspartate transaminase (r = +0.456, p < 0.001) and gamma-glutamyltransferase (r = +0.647, p < 0.001). Focusing on comorbid psychiatric disorders, we distinguish between patients with additional mental disorders (N = 61) and other substance use disorders (N = 38). Only CCL11 concentrations were found to be altered in AUD patients diagnosed with mental disorders (p < 0.01) with a strong main effect of sex. Thus, patients with mood disorders (N = 42) and/or anxiety (N = 16) had lower CCL11 concentrations than non-comorbid patients being more evident in women. The alcohol-induced alterations in circulating chemokines were also explored in preclinical models of alcohol use with male Wistar rats. Rats exposed to repeated ethanol (3 g/kg, gavage) had lower CXCL12 (p < 0.01) concentrations and higher CCL11 concentrations (p < 0.001) relative to vehicle-treated rats. Additionally, the increased CCL11 concentrations in rats exposed to ethanol were enhanced by the prior exposure to restraint stress (p < 0.01). Concordantly, acute ethanol exposure induced changes in CXCL12, CX3CL1, and CCL11 in the same direction to repeated exposure. These results clearly indicate a contribution of specific chemokines to the phenotype of AUD and a strong effect of sex, revealing a link of CCL11 to alcohol and anxiety/stress.
metadata.dc.identifier.doi: 10.3389/fpsyt.2016.00214
ISSN: 1664-0640 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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