Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2687
Título : A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of rat offspring in a sex-specific manner
Autor : Ramírez-López, María Teresa
Vázquez, Mariam
Lomazzo, Ermelinda
Hofmann, Clementine
Blanco, Rosario Noemi
Alén, Francisco
Antón, María
Decara, Juan
Arco, Rocío
Orio, Laura
Suárez, Juan
Lutz, Beat
Gómez de Heras, Raquel
Bindila, Laura
Rodríguez de Fonseca, Fernando
Filiación: [Ramírez-López,MT; Vázquez,M; Blanco,RN; Alén F; Antón,M; Orio,L; Gómez de Heras,R; Rodíguez de Fonseca,F] Departamento de Psicobiología. Facultad de Psicología, Universidad Complutense de Madrid, Pozuelo de Alarcón, Madrid, Spain, [Vázquez,M;Decara,J ; Arco,R; Suárez, J; Rodríguez de Fonseca, F] IBIMA, Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, Spain. [Lomazzo, E; Hofmann, C] Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany, [Suárez,J] Departamento de Biología Celular, Genética y Fisiología. IBIMA. Facultad de Ciencias, Universidad de Malaga. Campus de Teatinos s/n, Malaga, Spain.
Palabras clave : Desnutrición
Embarazo
Endocannabinoides
Ácido Araquidónico
Encéfalo
Animales recién nacidos
Ratas wistar
Femenino
Masculino
Emociones
Cognición
Restricción calórica
Hipotálamo
Hipocampo
Bulbo olfatorio
Peso al nacer
MeSH: Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Malnutrition
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy
Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Endocannabinoids
Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Arachidonic Acids
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain
Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Newborn
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Energy Intake::Caloric Restriction
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hypothalamus
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Olfactory Pathways::Olfactory Bulb
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Body Size::Body Weight::Birth Weight
Fecha de publicación : 27-Mar-2017
Editorial : Public Libray of Science
Cita Bibliográfica: Ramírez-López MT,Vázquez M, Lomazzo E, Hofmann C, Blanco RN, Alén F, et al. A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of rat offspring in a sex-specific manner. Plos One. 2017;12(3):e0174307.
Abstract: Undernutrition during pregnancy has been associated to increased vulnerability to develop metabolic and behavior alterations later in life. The endocannabinoid system might play an important role in these processes. Therefore, we investigated the effects of a moderate maternal calorie-restricted diet on the levels of the endocannabinoid 2-arachidonoyl glycerol (2-AG), arachidonic acid (AA) and the N-acylethanolamines (NAEs) anandamide (AEA), oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) in the brain of newborn rat offspring. We focused on brain structures involved in metabolism, feeding behavior, as well as emotional and cognitive responses. Female Wistar rats were assigned during the entire pregnancy to either control diet (C) or restriction diet (R), consisting of a 20% calorie-restricted diet. Weight gain and caloric intake of rat dams were monitored and birth outcomes were assessed. 2-AG, AA and NAE levels were measured in hypothalamus, hippocampus and olfactory bulb of the offspring. R dams displayed lower gain weight from the middle pregnancy and consumed less calories during the entire pregnancy. Offspring from R dams were underweight at birth, but litter size was unaffected. In hypothalamus, R male offspring displayed decreased levels of AA and OEA, with no change in the levels of the endocannabinoids 2-AG and AEA. R female exhibited decreased 2-AG and PEA levels. The opposite was found in the hippocampus, where R male displayed increased 2-AG and AA levels, and R female exhibited elevated levels of AEA, AA and PEA. In the olfactory bulb, only R female presented decreased levels of AEA, AA and PEA. Therefore, a moderate diet restriction during the entire pregnancy alters differentially the endocannabinoids and/or endocannabinoid-related lipids in hypothalamus and hippocampus of the underweight offspring, similarly in both sexes, whereas sex-specific alterations occur in the olfactory bulb. Consequently, endocannabinoid and endocannabinoid-related lipid signaling alterations might be involved in the long-term and sexual dimorphism effects commonly observed after undernutrition and low birth weight.
Descripción : Existe para su consulta material suplementario aportado por el editor.
URI: http://hdl.handle.net/10668/2687
Versión del editor : http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174307
DOI: 10.1371/journal.pone.0174307
ISSN : 1932-6203 (Online)
Appears in Collections:01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - Hospital Regional de Málaga

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