Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2691
Título : The Escape of Cancer from T Cell-Mediated Immune Surveillance: HLA Class I Loss and Tumor Tissue Architecture
Autor : Garrido, Federico
Perea, Francisco
Bernal, Mónica
Sánchez-Palencia, Abel
Aptsiauri, Natalia
Ruiz-Cabello, Francisco
Filiación: [Garrido,F; Perea,F; Bernal,M; Ruiz-Cabello,F] Servicio de Analisis Clinicos e Inmunologia, UGC Laboratorio Clinico, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Garrido,F; Aptsiauri,N; Ruiz-Cabello,F] Instituto de Investigacion Biosanitaria ibs.Granda, Granada, Spain. Departamento de Bioquimica, Biologia Molecular e Inmunologia III, Facultad de Medicina, Universidad de Granada, Granada, Spain. [Sánchez-Palencia,A] Unidad de Cirugía Torácica, Hospital Universitario Virgen de las Nieves, Granada, Spain.
Palabras clave : HLA class I loss
Tumor infiltrating lymphocytes (TILs)
Tumor immune escape
Humanos
Inmunoterapia
Activación de linfocitos
Macrófagos
Mutación
Neoplasia
Linfocitos t citotóxicos
Escape del Tumor
Microambiente tumoral
MeSH: Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Lymphocyte Activation
Medical Subject Headings::Anatomy::Cells::Phagocytes::Macrophages
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation
Medical Subject Headings::Diseases::Neoplasms
Medical Subject Headings::Anatomy::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::Lymphocyte Subsets::T-Lymphocyte Subsets::T-Lymphocytes, Cytotoxic
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Tumor Escape
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
Fecha de publicación : 27-Feb-2017
Editorial : MDPI
Cita Bibliográfica: Garrido F, Perea F, Bernal M, Sánchez-Palencia A, Aptsiauri N, Ruiz-Cabello F. The Escape of Cancer from T Cell-Mediated Immune Surveillance: HLA Class I Loss and Tumor Tissue Architecture. Vaccines (Basel). 2017;5(1). pii: E7
Abstract: Tumor immune escape is associated with the loss of tumor HLA class I (HLA-I) expression commonly found in malignant cells. Accumulating evidence suggests that the efficacy of immunotherapy depends on the expression levels of HLA class I molecules on tumors cells. It also depends on the molecular mechanism underlying the loss of HLA expression, which could be reversible/"soft" or irreversible/"hard" due to genetic alterations in HLA, β2-microglobulin or IFN genes. Immune selection of HLA-I negative tumor cells harboring structural/irreversible alterations has been demonstrated after immunotherapy in cancer patients and in experimental cancer models. Here, we summarize recent findings indicating that tumor HLA-I loss also correlates with a reduced intra-tumor T cell infiltration and with a specific reorganization of tumor tissue. T cell immune selection of HLA-I negative tumors results in a clear separation between the stroma and the tumor parenchyma with leucocytes, macrophages and other mononuclear cells restrained outside the tumor mass. Better understanding of the structural and functional changes taking place in the tumor microenvironment may help to overcome cancer immune escape and improve the efficacy of different immunotherapeutic strategies. We also underline the urgent need for designing strategies to enhance tumor HLA class I expression that could improve tumor rejection by cytotoxic T-lymphocytes (CTL).
Descripción : (This article belongs to the Special Issue Mechanisms of Tumor Escape from Host Immunity)
URI: http://hdl.handle.net/10668/2691
Versión del editor : http://www.mdpi.com/2076-393X/5/1/7
DOI: 10.3390/vaccines5010007
ISSN : 2076-393X (Online)
Appears in Collections:01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada
01- Artículos - Complejo Hospitalario Universitario de Granada

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