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Title: Parental occupational exposure to organic solvents and anencephaly in Mexico
Authors: Aguilar-Garduño, Clemente
Lacasaña, Marina
Blanco-Muñoz, J.
Borja-Aburto, V. Hugo
García, A.M.
metadata.dc.contributor.authoraffiliation: [Aguilar-Garduño, C; Lacasaña, M]. Andalusian School of Public Health. [Aguilar-Garduño, C] Andalusian Observatory of Environmental Health. [Lacasana, M] CIBER Epidemiology & Public Health CIBERESP. [Blanco-Muñoz, J] National Institute of Public Health, Mexico. [Hugo Borja-Aburto, V] Mexican Institute of Social Security. [Garcia, A. M] University of Valencia, Department of Preventive Medicine & Public Health
Keywords: Occupational exposure;Exposición profesional;Anencephaly;Anencefalia;Solvents;Solventes;Mexico
metadata.dc.subject.mesh: Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Occupational Exposure
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Solvents
Medical Subject Headings::Diseases::Congenital, Hereditary, and Neonatal Diseases and Abnormalities::Congenital Abnormalities::Abnormalities, Severe Teratoid::Anencephaly
Medical Subject Headings::Geographicals::Geographic Locations::Americas::North America::Mexico
Issue Date: 2010
Publisher: BMJ Publishing Group
Citation: Aguilar-Garduño C, Lacasaña M, Blanco-Muñoz J, Borja-Aburto VH, García AM. Parental occupational exposure to organic solvents and anencephaly in Mexico. Occup Environ Med. 2010 Jan;67(1):32-7
Abstract: Objective: To assess the relationship between parental occupational exposure to organic solvents, and the risk of anencephaly in Mexico. Methods: A case-control study was conducted based on the registers of the Epidemiological Surveillance System for Neural Tube Defects in Mexico; 151 cases of anencephaly of ≥20 weeks’ gestation were included. A control, born alive and without any apparent congenital malformations at birth, was selected for each case in the same maternity service in which the case was born. Information on occupational exposures, lifestyle habits, reproductive history, use of medicines, supplementation with multivitamins and folic acid, was obtained by a general questionnaire; a food frequency questionnaire was also applied to obtain information of daily intake of folate and other B vitamins. Occupational exposure to organic solvents was based on job title as a proxy for exposure and analysed considering two critical periods around conception. Results: In logistic regression analysis, the odds of having a child with anencephaly was higher if the mother or the father was occupationally exposed to organic solvents during the periconceptional period, or when both parents or at least one of them were occupationally exposed during this period with an adjusted odds ratio of 2.97 (95% CI 1.36 to 6.52). Conclusions: The results support the hypothesis that both maternal and paternal occupational exposure to organic solvents can increase the probability of having a child with anencephaly.
metadata.dc.identifier.doi: 10.1136/oem.2008.044743
Appears in Collections:01- Artículos - EASP. Escuela Andaluza de Salud Pública

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