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Título : Inter-Reader Reliability of Early FDG-PET/CT Response Assessment Using the Deauville Scale after 2 Cycles of Intensive Chemotherapy (OEPA) in Hodgkin's Lymphoma.
Autor : Kluge, Regine
Chavdarova, Lidia
Hoffmann, Martha
Kobe, Carsten
Malkowski, Bogdan
Montravers, Françoise
Kurch, Lars
Georgi, Thomas
Dietlein, Markus
Wallace, W Hamish
Karlen, Jonas
Fernández-Teijeiro, Ana
Cepelova, Michaela
Wilson, Lorrain
Bergstraesser, Eva
Sabri, Osama
Mauz-Körholz, Christine
Körholz, Dieter
Hasenclever, Dirk
Filiación: [Kluge,R; Kurch,L; Georgi,T; Sabri,O] Department of Nuclear Medicine, University of Leipzig, Leipzig, Germany. [Chavdarova,L] Clinic of Nuclear Medicine, National Hospital for Active Treatment in Oncology, Sofia, Bulgaria. [Hoffmann,M] Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria. [Kobe,C; Dietlein,M] Department of Nuclear Medicine, University Hospital of Cologne, Cologne, Germany. [Malkowski,B] Dept. of PET and Molecular Imaging, Nicolaus Copernicus University, Collegium MedicumBydgoszcz, Poland. [Montravers,F] Department of Nuclear Medicine, Hopital Tenon, Assistance Publique Hôpitaux de Paris, Faculté de médecine Pierre et Marie Curie, Paris, France. [Wallace,WH] Department of Paediatric Oncology, Royal Hospital for Sick Children, University of Edinburgh, Edinburgh, United Kingdom. [Karlen,J] Karolinska University Hospital, Astrid Lindgrens Childrens Hospital, Stockholm, Sweden. [Fernández-Teijeiro,A] Pediatric Oncology Unit, Hospitales Universitarios Virgen Macarena y Virgen del Rocio, Sevilla, Spain. [Cepelova,M] Department of Pediatric Hematology and Oncology, University Hospital Motol and 2nd Medical Faculty of Charles University, Prague, Czech Republic. [Wilson,L] Department of Nuclear Medicine, Blackrock Clinic, Dublin, Ireland. [Bergstraesser.e] Department of Paediatric Oncology, University Children’s Hospital Zurich, Switzerland. [Mauz-Körholz,C; Körholz,D] Department of Pediatric Oncology, University of Halle, Halle/Saale, Germany. [Hasenclever,D] Institute for Medical Informatics, Statistics and Epidemiology (IMISE), University of Leipzig, Leipzig, Germany.
Palabras clave : Ensayo clínico controlado aleatorio
Enfermedad de Hodgkin
Sistema musculoesquelético
Estudio multicéntrico
Brown adipose tissue
Positron emission tomography
Hodgkin lymphoma
Lymph nodes
MeSH: Medical Subject Headings::Named Groups::Persons::Age Groups::Child
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Hodgkin Disease
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Publication Type::Study Characteristics::Multicenter Study
Medical Subject Headings::Anatomy::Musculoskeletal System
Medical Subject Headings::Publication Type::Study Characteristics::Clinical Trial::Randomized Controlled Trial
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Laboratory Chemicals::Indicators and Reagents::Radiopharmaceuticals
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Reproducibility of Results
Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Tomography::Tomography, X-Ray::Tomography, X-Ray Computed
Medical Subject Headings::Persons::Persons::Age Groups::Adolescent
Fecha de publicación : 10-Mar-2016
Editorial : Public Library of Science
Cita Bibliográfica: Kluge R, Chavdarova L, Hoffmann M, Kobe C, Malkowski B, Montravers F, et al. Inter-Reader Reliability of Early FDG-PET/CT Response Assessment Using the Deauville Scale after 2 Cycles of Intensive Chemotherapy (OEPA) in Hodgkin's Lymphoma. PLoS ONE. 2016; 11(3):e0149072
Abstract: Purpose The five point Deauville (D) scale is widely used to assess interim PET metabolic response to chemotherapy in Hodgkin lymphoma (HL) patients. An International Validation Study reported good concordance among reviewers in ABVD treated advanced stage HL patients for the binary discrimination between score D1,2,3 and score D4,5. Inter-reader reliability of the whole scale is not well characterised. METHODS Five international expert readers scored 100 interim PET/CT scans from paediatric HL patients. Scans were acquired in 51 European hospitals after two courses of OEPA chemotherapy (according to the EuroNet-PHL-C1 study). Images were interpreted in direct comparison with staging PET/CTs. RESULTS The probability that two random readers concord on the five point D score of a random case is only 42% (global kappa = 0.24). Aggregating to a three point scale D1,2 vs. D3 vs. D4,5 improves concordance to 60% (kappa = 0.34). Concordance if one of two readers assigns a given score is 70% for score D1,2 only 36% for score D3 and 64% for D4,5. Concordance for the binary decisions D1,2 vs. D3,4,5 is 67% and 86% for D1,2,3 vs D4,5 (kappa = 0.36 resp. 0.56). If one reader assigns D1,2,3 concordance probability is 92%, but only 64% if D4,5 is called. Discrepancies occur mainly in mediastinum, neck and skeleton. CONCLUSION Inter-reader reliability of the five point D-scale is poor in this interobserver analysis of paediatric patients who underwent OEPA. Inter-reader variability is maximal in cases assigned to D2 or D3. The binary distinction D1,2,3 versus D4,5 is the most reliable criterion for clinical decision making.
Descripción : Journal Article;
Versión del editor :
DOI: 10.1371/journal.pone.0149072
ISSN : 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Virgen del Rocío
01- Artículos - Hospital Virgen Macarena

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