Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2858
Título : LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus
Autor : Cobo-Vuilleumier, Nadia
Lorenzo, Petra I.
García Rodríguez, Noelia
Herrera Gómez, Irene de Gracia
Fuente-Martin, Esther
López-Noriega, Livia
Mellado-Gil, José Manuel
Romero-Zerbo, Silvana-Yanina
Baquié, Mathurin
Lachaud, Christian Claude
Stifter, Katja
German, Perdomo
Marco, Bugliani
De Tata, Vincenzo
Bosco, Domenico
Parnaud, Geraldine
Pozo, David
Hmadcha, Abdelkrim
Florido, Javier P.
Toscano, Miguel G.
de Haan, Peter
Schoonjans, Kristina
Sánchez Palazón, Luis
Marchetti, Piero
Schirmbeck, Reinhold
Martín-Montalvo, Alejandro
Meda, Paolo
Soria, Bernat
Bermúdez-Silva, Francisco-Javier
St-Onge, Luc
Gauthier, Benoit R.
Filiación: [Cobo-Vuilleumier,N; Lorenzo,PI; García Rodríguez,N; Herrera Gómez,IG; Fuente-Martin,E; López-Noriega,L; Mellado-Gil,JM; Claude Lachaud,C; Hmadcha,A; Martín-Montalvo,A; Soria,B; Gauthier, BR] Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucia-University of Pablo de Olavide-University of Seville-CSIC, Seville, 41092, Spain. [Romero-Zerbo,SY; Bermúdez-Silva,FJ] Unidad de Gestión Clínica Intercentros de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga (IBIMA) Hospital Regional Universitario de Málaga, Universidad de Málaga, Málaga, 29010, Spain. [Romero-Zerbo,SY; Hmadcha,A; Soria,B; Bermúdez-Silva,FJ] Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, 28029, Spain. [Baquié,M] Neurix SA, Geneva, 1228, Switzerland. [Stifter,K; Schirmbeck,R] Ulm University Hospital, Ulm, 89081, Germany. [Perdomo,G] Facultad de Ciencias de la Salud, Universidad de Burgos, Burgos, 09001, Spain. [Bugliani,M; Marchetti,P] Department Clinical and Experimental Medicine, University of Pisa—AOUP University Hospital, Pisa, 56126, Italy. [De Tata,V] Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, 56126, Italy. [Bosco,D; Parnaud,G] Cell Isolation and Transplantation Centre, University Hospital, Geneva, 1211, Switzerland. [Pozo,D] Department of Cell Dynamics and Signalling, CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, 41092, Spain. [Florido,JP] Clinical Bioinformatics Area, Fundación Progreso y Salud, Consejería de Salud, Seville, 41013, Spain. [Toscano,MG; de Haan,P] Amarna Therapeutics, Seville, 41092, Spain. [Schoonjans,K] Laboratory of Metabolic Signaling, EPFL, Lausanne, 1015, Switzerland. [Sánchez Palazón,L] Biological Resources, CABIMER-Andalusian Center for Molecular Biology and Regenerative Medicine, Seville, 41092, Spain. [Meda,P] Department of Cell Physiology and Metabolism, University of Geneva, Geneva, 1211, Switzerland. [St-Onge,L] Neuried Munich, 82061, Germany.
Palabras clave : Islets of Langerhans
Type 1 diabetes
Type 2 diabetes
Islotes Pancreáticos
Diabetes Mellitus Tipo 1
Diabetes Mellitus Tipo 2
Diabetes Mellitus
Diabetes
MeSH: Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 1
Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2
Medical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Islets of Langerhans
Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae
Medical Subject Headings::Organisms::Eukaryota::Animals
Fecha de publicación : 16-Apr-2018
Editorial : Springer Nature
Cita Bibliográfica: Cobo-Vuilleumier, N; Lorenzo, PI; García Rodríguez, N; Herrera Gómez, IG; Fuente-Martin, E; López-Noriega, L, et al. LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus. Nature Communications. 2018;9(1):1488
Abstract: Type 1 diabetes mellitus (T1DM) is due to the selective destruction of islet beta cells by immune cells. Current therapies focused on repressing the immune attack or stimulating beta cell regeneration still have limited clinical efficacy. Therefore, it is timely to identify innovative targets to dampen the immune process, while promoting beta cell survival and function. Liver receptor homologue-1 (LRH-1) is a nuclear receptor that represses inflammation in digestive organs, and protects pancreatic islets against apoptosis. Here, we show that BL001, a small LRH-1 agonist, impedes hyperglycemia progression and the immune-dependent inflammation of pancreas in murine models of T1DM, and beta cell apoptosis in islets of type 2 diabetic patients, while increasing beta cell mass and insulin secretion. Thus, we suggest that LRH-1 agonism favors a dialogue between immune and islet cells, which could be druggable to protect against diabetes mellitus.
URI: http://hdl.handle.net/10668/2858
Versión del editor : https://www.nature.com/articles/s41467-018-03943-0
DOI: 10.1038/s41467-018-03943-0
ISSN : 2041-1723 (Online)
Appears in Collections:01 - Artículos - Fundación Pública Andaluza Progreso y Salud
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - CABIMER. Centro Andaluz de Biología Molecular

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