Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/287
Title: Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers
Authors: Domínguez-Sánchez, María S.
Sáez, Carmen
Japón, Miguel A.
Aguilera, Andrés
Luna, Rosa
metadata.dc.contributor.authoraffiliation: [Domínguez-Sánchez MS, Aguilera A, Luna R] Centro Andaluz de Biología Molecular y Medicina Regenerativa CABIMER, Universidad de Sevilla-CSIC, Sevilla, Spain. [Sáez,C; Japón,MA]Instituto de Biomedicina de Sevilla (IBIS) and Department of Pathology, Hospital Universitario Virgen del Rocío/Universidad de Sevilla/CSIC.
Keywords: Neoplasias de la Mama;Proteínas Nucleares;Ribonucleoproteínas;Proteínas de Unión al ARN;Proteínas de Ciclo Celular
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Nuclear Proteins
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Carrier Proteins::RNA-Binding Proteins::Ribonucleoproteins
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins:: Proteins::Cell Cycle Proteins
Issue Date: 17-Feb-2011
Publisher: BioMed Central
Citation: Domínguez-Sánchez MS, Sáez C, Japón MA, Aguilera A, Luna R. Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers. BMC Cancer. 2011 Feb 17;11:77.
Abstract: One key step in gene expression is the biogenesis of mRNA ribonucleoparticle complexes (mRNPs). Formation of the mRNP requires the participation of a number of conserved factors such as the THO complex. THO interacts physically and functionally with the Sub2/UAP56 RNA-dependent ATPase, and the Yra1/REF1/ALY RNA-binding protein linking transcription, mRNA export and genome integrity. Given the link between genome instability and cancer, we have performed a comparative analysis of the expression patterns of THOC1, a THO complex subunit, and ALY in tumor samples.
URI: http://hdl.handle.net/10668/287
metadata.dc.relation.publisherversion: http://www.biomedcentral.com/1471-2407/11/77
metadata.dc.identifier.doi: 10.1186/1471-2407-11-77
ISSN: 1471-2407 (Online)
Appears in Collections:01- Artículos - CABIMER. Centro Andaluz de Biología Molecular
01- Artículos - Hospital Virgen del Rocío
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla

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