Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/296
Title: Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain
Authors: Ballester, Ferrán
Estarlich, Marina
Iñiguez, Carmen
Llop, Sabrina
Ramón, Rosa
Esplugues, Ana
Lacasaña, Marina
Rebagliato, Marisa
metadata.dc.contributor.authoraffiliation: [Ballester, F; Estarlich, M; Iniguez, C; Llop, S; Esplugues, A] Center for Public Health Research (CSISP) Valencia, Spain. [Ballester, F; Estarlich, M; Iniguez, C; Llop, S; Ramon, R; Esplugues, A; Lacasaña, M; Rebagliato, M] Spanish Consortium for Research on Epidemiology & Public Health (CIBERESP), Barcelona, Spain. [Ballester, F] Universidad de Valencia, School of Nursing, Valencia, Spain. [Ramon, R] General Directorate of Public Health, Valencia, Spain. [Lacasaña, M] Andalusian School of Public Health (EASP), Granada, Spain. [Rebagliato, M] Rey Juan Carlos University, Department of Public Health, Madrid, Spain.
Keywords: Contaminantes del aire;Exposición materna;Embarazo;Valencia;Estudios prospectivos
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Toxic Actions::Environmental Pollutants::Air Pollutants
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Environmental Pollution::Environmental Exposure::Maternal Exposure
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy
Medical Subject Headings::Geographicals::Geographic Locations::Europe::Spain
Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Prospective Studies
Issue Date: 29-Jan-2010
Publisher: Biomed Central
Citation: Ballester F, Estarlich M, Iñiguez C, Llop S, Ramón R, Esplugues A, et al. Air pollution exposure during pregnancy and reduced birth size: a prospective birth cohort study in Valencia, Spain. Environ Health. 2010 Jan 29; 9:6
Abstract: Background Maternal exposure to air pollution has been related to fetal growth in a number of recent scientific studies. The objective of this study was to assess the association between exposure to air pollution during pregnancy and anthropometric measures at birth in a cohort in Valencia, Spain. Methods Seven hundred and eighty-five pregnant women and their singleton newborns participated in the study. Exposure to ambient nitrogen dioxide (NO2) was estimated by means of land use regression. NO2 spatial estimations were adjusted to correspond to relevant pregnancy periods (whole pregnancy and trimesters) for each woman. Outcome variables were birth weight, length, and head circumference (HC), along with being small for gestational age (SGA). The association between exposure to residential outdoor NO2 and outcomes was assessed controlling for potential confounders and examining the shape of the relationship using generalized additive models (GAM). Results For continuous anthropometric measures, GAM indicated a change in slope at NO2 concentrations of around 40 μg/m3. NO2 exposure >40 μg/m3 during the first trimester was associated with a change in birth length of -0.27 cm (95% CI: -0.51 to -0.03) and with a change in birth weight of -40.3 grams (-96.3 to 15.6); the same exposure throughout the whole pregnancy was associated with a change in birth HC of -0.17 cm (-0.34 to -0.003). The shape of the relation was seen to be roughly linear for the risk of being SGA. A 10 μg/m3 increase in NO2 during the second trimester was associated with being SGA-weight, odds ratio (OR): 1.37 (1.01-1.85). For SGA-length the estimate for the same comparison was OR: 1.42 (0.89-2.25). Conclusions Prenatal exposure to traffic-related air pollution may reduce fetal growth. Findings from this study provide further evidence of the need for developing strategies to reduce air pollution in order to prevent risks to fetal health and development.
URI: http://hdl.handle.net/10668/296
metadata.dc.relation.publisherversion: http://www.ehjournal.net/content/9/1/6
metadata.dc.identifier.doi: 10.1186/1476-069X-9-6
Appears in Collections:01- Artículos - EASP. Escuela Andaluza de Salud Pública

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