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http://hdl.handle.net/10668/3148| Title: | Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration |
| Authors: | Aguareles, José Paraíso-Luna, Juan Palomares, Belén Bajo-Grañeras, Raquel Navarrete, Carmen Ruiz-Calvo, Andrea García-Rincón, Daniel García-Taboada, Elena Guzmán, Manuel Muñoz, Eduardo Galve-Roperh, Ismael |
| metadata.dc.contributor.authoraffiliation: | [Aguareles,J; Paraíso-Luna,J; Bajo-Grañeras,R; Ruiz-Calvo,A; García-Rincón,D; García-Taboada,E; Guzmán,M; Galve-Roperh,I] Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, Spain. [Aguareles,J; Paraíso-Luna,J; Bajo-Grañeras,R; Ruiz-Calvo,A; García-Rincón,D; García-Taboada,E; Guzmán,M; Galve-Roperh,I] Departamento de Bioquímica y Biología Molecular and Instituto Universitario de Investigación Neuroquímica, Universidad Complutense, Madrid, Spain. [Aguareles,J; Paraíso-Luna,J; Bajo-Grañeras,R; Ruiz-Calvo,A; García-Rincón,D; García-Taboada,E; Guzmán,M; Galve-Roperh,I] Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. [Palomares,B; Muñoz,E] Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. [Palomares,B; Muñoz,E] Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Córdoba, Spain. [Palomares,B; Muñoz,E] Hospital Universitario Reina Sofía, Córdoba, Spain. [Navarrete,C] Emerald Health Pharmaceuticals, San Diego, USA. |
| Keywords: | Cannabinoid;Huntingtin;Neurodegeneration;Neurogenesis;PPAR;Cannabinoides;Proteína huntingtina;Enfermedades neurodegenerativas;Neurodegenerative diseases;Neurogénesis;Peroxisome proliferator-activated receptors;Receptores activados del proliferador del peroxisoma |
| metadata.dc.subject.mesh: | Medical Subject Headings::Diseases::Nervous System Diseases::Neurodegenerative Diseases Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::Cannabinoids Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation::Neurogenesis Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Receptors, Cytoplasmic and Nuclear::Peroxisome Proliferator-Activated Receptors Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans |
| Issue Date: | 8-Mar-2019 |
| Publisher: | BioMed Central Ltd. |
| Citation: | Aguareles J, Paraíso-Luna J, Palomares B, Bajo-Grañeras R, Navarrete C, Ruiz-Calvo A, et al. Oral administration of the cannabigerol derivative VCE-003.2 promotes subventricular zone neurogenesis and protects against mutant huntingtin-induced neurodegeneration. Transl Neurodegener. 2019 Mar 8;8:9. |
| Abstract: | The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous system are mediated by CB1 receptors, which can elicit psychotropic effects, but other targets devoid of psychotropic activity, including CB2 and nuclear PPARγ receptors, can also be the target of specific cannabinoids. |
| URI: | http://hdl.handle.net/10668/3148 |
| metadata.dc.relation.publisherversion: | https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-019-0148-x |
| metadata.dc.identifier.doi: | 10.1186/s40035-019-0148-x |
| ISSN: | 2047-9158 (Online) |
| Appears in Collections: | 01- Artículos - Hospital Reina Sofía 01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Aguareles_OralAdministrationOfThe.pdf | Artículo publicado | 9,45 MB | Adobe PDF | View/Open |
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