Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3149
Título : Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis
Autor : Roy, Alvaro
Tomé, Irene
Romero, Beatriz
Lorente-Leal, Víctor
Infantes-Lorenzo, José A
Domínguez, Mercedes
Martín, Carlos
Aguiló, Nacho
Puentes, Eugenia
Rodríguez, Esteban
de Juan, Lucía
Risalde, María A
Gortázar, Christian
Domínguez, Lucas
Bezos, Javier
Filiación: [Roy,A; Puentes,E; Rodríguez,E] BIOFABRI S.L., Porriño, Pontevedra, Spain. [Roy,A; Tomé,I; Romero,B; Lorente-Leal,V; Infantes-Lorenzo,JA; de Juan,L; Domínguez,L; Bezos,J] VISAVET Health Surveillance Centre, Universidad Complutense de Madrid, Madrid, Spain. [Domínguez,M] Servicio de Inmunología Microbiana, Centro Nacional de Microbiología, Instituto de Investigación Carlos III, Majadahonda, Madrid, Spain. [Martín,C; Aguiló,N] Grupo de Genética de Micobacterias, Departamento de Microbiología y Medicina Preventiva, Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain. [Martín,C; Aguiló,N] CIBER Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. [Martín,C] Servicio de Microbiología, Hospital Universitario Miguel Servet, IIS Aragón, Zaragoza, Spain. [de Juan,L; Domínguez,L; Bezos,J] Dpto. de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense de Madrid, Madrid, Spain. [Risalde,MA] Dpto. de Anatomía y Anatomía Patológica Comparadas, Universidad de Córdoba, Córdoba, Spain. [Risalde,MA] Infectious Diseases Unit, Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Hospital Universitario Reina Sofía de Córdoba, Universidad de Córdoba, Córdoba, Spain. [Gortázar,C] SaBio (Health and Biotechnology), Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM), Ciudad Real, Spain.
Palabras clave : BCG Vaccine
Vacuna BCG
Mycobacterium tuberculosis
Tuberculosis
Mycobacterium bovis
Infecciones por mycobacterium
Mycobacterium infections
Bacterial vaccines
Vacunas bacterianas
Natural transmission
Transmisión natural
Goats
Cabra
Animals
Humans
MeSH: Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Products::Vaccines::Bacterial Vaccines::Tuberculosis Vaccines::BCG Vaccine
Medical Subject Headings::Diseases::Animal Diseases::Goat Diseases
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Artiodactyla::Ruminants::Goats
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Cellular
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Humoral
Medical Subject Headings::Organisms::Bacteria::Gram-Negative Bacteria::Tenericutes::Mycoplasmatales::Mycoplasmataceae::Mycoplasma
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Actinomycetales Infections::Mycobacterium Infections::Tuberculosis
Medical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Products::Vaccines::Bacterial Vaccines::Tuberculosis Vaccines
Medical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Products::Vaccines::Vaccines, Attenuated
Medical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Actinobacteria::Actinomycetales::Mycobacteriaceae::Mycobacterium::Mycobacterium tuberculosis
Fecha de publicación : 15-Oct-2019
Editorial : BioMed Central Ltd.
Cita Bibliográfica: Roy A, Tomé I, Romero B, Lorente-Leal V, Infantes-Lorenzo JA, Domínguez M, et al. Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis. Vet Res. 2019 Oct 15;50:82.
Abstract: Effective vaccines against tuberculosis (TB) are needed in order to prevent TB transmission in human and animal populations. Evaluation of TB vaccines may be facilitated by using reliable animal models that mimic host pathophysiology and natural transmission of the disease as closely as possible. In this study, we evaluated the immunogenicity and efficacy of two attenuated vaccines, BCG and MTBVAC, after each was given to 17 goats (2 months old) and then exposed for 9 months to goats infected with M. caprae. In general, MTBVAC-vaccinated goats showed higher interferon-gamma release than BCG vaccinated goats in response to bovine protein purified derivative and ESAT-6/CFP-10 antigens and the response was significantly higher than that observed in the control group until challenge. All animals showed lesions consistent with TB at the end of the study. Goats that received either vaccine showed significantly lower scores for pulmonary lymph nodes and total lesions than unvaccinated controls. Both MTBVAC and BCG vaccines proved to be immunogenic and effective in reducing severity of TB pathology caused by M. caprae. Our model system of natural TB transmission may be useful for evaluating and optimizing vaccines.
URI: http://hdl.handle.net/10668/3149
Versión del editor : https://veterinaryresearch.biomedcentral.com/articles/10.1186/s13567-019-0702-7
DOI: 10.1186/s13567-019-0702-7
ISSN : 0928-4249 (Print)
1297-9716 (Online)
Appears in Collections:01- Artículos - Hospital Reina Sofía
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba

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