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http://hdl.handle.net/10668/3150| Title: | Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion |
| Authors: | Muñoz-Fernández, Raquel De La Mata, Claudia Requena, Francisco Martín, Francisco Fernandez-Rubio, Pablo Llorca, Tatiana Ruiz-Magaña, Maria José Ruiz-Ruiz, Carmen Olivares, Enrique G. |
| metadata.dc.contributor.authoraffiliation: | [Munoz-Fernandez,R; De La Mata,C; Fernandez-Rubio,P; Llorca,T; Ruiz-Magana,MJ; Ruiz-Ruiz,C; Olivares,EG] Instituto de Biopatología y Medicina Regenerativa, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain. [Requena,F] Departamento de Estadística e Investigación Operativa, Universidad de Granada, Granada, Spain. [Martín,F] Human DNA Variability Department, GENYO - Centre for Genomic and Oncological Research (Pfizer/University of Granada/Andalusian Regional Government), PTS Granada, Granada, Spain. [Ruiz-Ruiz,C; Olivares,EG] Departamento de Bioquímica y Biología Molecular III e Inmunología, Facultad de Medicina, Universidad de Granada, Granada, Spain. [Olivares,EG] Unidad de Gestión Clínica Laboratorios, Hospital Universitario San Cecilio, Granada, Spain. |
| Keywords: | Clone cells;Decidua;Immune tolerance;Immunotherapy;Mesenchymal stromal cells;Predecidual stromal cells;Recurrent abortion;Células clonales;Tolerancia inmunológica;Inmunoterapia;Células madre mesenquimatosas;Aborto habitual |
| metadata.dc.subject.mesh: | Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Abortion, Spontaneous::Abortion, Habitual Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Abortion, Spontaneous Medical Subject Headings::Organisms::Eukaryota::Animals Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation Medical Subject Headings::Anatomy::Cells::Cells, Cultured Medical Subject Headings::Anatomy::Embryonic Structures::Placenta::Decidua Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal Medical Subject Headings::Anatomy::Urogenital System::Genitalia::Genitalia, Female::Uterus::Endometrium Medical Subject Headings::Check Tags::Female Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Mesenchymal Stem Cell Transplantation Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy |
| Issue Date: | 14-Jun-2019 |
| Publisher: | BioMed Central Ltd. |
| Citation: | Muñoz-Fernández R, De La Mata C, Requena F, Martín F, Fernandez-Rubio P, Llorca T, et al. Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion. Stem Cell Res Ther. 2019 Jun 14;10(1):177. |
| Abstract: | Human decidual stromal cells (DSCs) are involved in the maintenance and development of pregnancy, in which they play a key role in the induction of immunological maternal-fetal tolerance. Precursors of DSCs (preDSCs) are located around the vessels, and based on their antigen phenotype, previous studies suggested a relationship between preDSCs and mesenchymal stromal/stem cells (MSCs). This work aimed to further elucidate the MSC characteristics of preDSCs. |
| URI: | http://hdl.handle.net/10668/3150 |
| metadata.dc.relation.publisherversion: | https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1284-z |
| metadata.dc.identifier.doi: | 10.1186/s13287-019-1284-z |
| ISSN: | 1757-6512 (Online) |
| Appears in Collections: | 01- Artículos - GENYO. Centro Pfizer-Andalucía de Genómica e Investigación Oncológica 01- Artículos - Hospital San Cecilio |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| MuñozFernandez_HumanPredecidual.pdf | Artículo publicado | 1,79 MB | Adobe PDF | View/Open |
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