Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3150
Título : Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion
Autor : Muñoz-Fernández, Raquel
De La Mata, Claudia
Requena, Francisco
Martín, Francisco
Fernandez-Rubio, Pablo
Llorca, Tatiana
Ruiz-Magaña, Maria José
Ruiz-Ruiz, Carmen
Olivares, Enrique G.
Filiación: [Munoz-Fernandez,R; De La Mata,C; Fernandez-Rubio,P; Llorca,T; Ruiz-Magana,MJ; Ruiz-Ruiz,C; Olivares,EG] Instituto de Biopatología y Medicina Regenerativa, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain. [Requena,F] Departamento de Estadística e Investigación Operativa, Universidad de Granada, Granada, Spain. [Martín,F] Human DNA Variability Department, GENYO - Centre for Genomic and Oncological Research (Pfizer/University of Granada/Andalusian Regional Government), PTS Granada, Granada, Spain. [Ruiz-Ruiz,C; Olivares,EG] Departamento de Bioquímica y Biología Molecular III e Inmunología, Facultad de Medicina, Universidad de Granada, Granada, Spain. [Olivares,EG] Unidad de Gestión Clínica Laboratorios, Hospital Universitario San Cecilio, Granada, Spain.
Palabras clave : Clone cells
Decidua
Immune tolerance
Immunotherapy
Mesenchymal stromal cells
Predecidual stromal cells
Recurrent abortion
Células clonales
Tolerancia inmunológica
Inmunoterapia
Células madre mesenquimatosas
Aborto habitual
MeSH: Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Abortion, Spontaneous::Abortion, Habitual
Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Abortion, Spontaneous
Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation
Medical Subject Headings::Anatomy::Cells::Cells, Cultured
Medical Subject Headings::Anatomy::Embryonic Structures::Placenta::Decidua
Medical Subject Headings::Diseases::Animal Diseases::Disease Models, Animal
Medical Subject Headings::Anatomy::Urogenital System::Genitalia::Genitalia, Female::Uterus::Endometrium
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Mesenchymal Stem Cell Transplantation
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancy
Fecha de publicación : 14-Jun-2019
Editorial : BioMed Central Ltd.
Cita Bibliográfica: Muñoz-Fernández R, De La Mata C, Requena F, Martín F, Fernandez-Rubio P, Llorca T, et al. Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion. Stem Cell Res Ther. 2019 Jun 14;10(1):177.
Abstract: Human decidual stromal cells (DSCs) are involved in the maintenance and development of pregnancy, in which they play a key role in the induction of immunological maternal-fetal tolerance. Precursors of DSCs (preDSCs) are located around the vessels, and based on their antigen phenotype, previous studies suggested a relationship between preDSCs and mesenchymal stromal/stem cells (MSCs). This work aimed to further elucidate the MSC characteristics of preDSCs.
URI: http://hdl.handle.net/10668/3150
Versión del editor : https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1284-z
DOI: 10.1186/s13287-019-1284-z
ISSN : 1757-6512 (Online)
Appears in Collections:01- Artículos - Hospital San Cecilio
01- Artículos - GENYO. Centro Pfizer-Andalucía de Genómica e Investigación Oncológica

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