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Title: Signaling pathways involved in colorectal cancer progression
Authors: Koveitypour, Zahra
Panahi, Farnoush
Vakilian, Mehrdad
Peymani, Maryam
Seyed Forootan, Farzad
Nasr Esfahani, Mohammad Hossein
Ghaedi, Kamran
metadata.dc.contributor.authoraffiliation: [Koveitypour,Z; Panahi,F] Department of Modern Biology, ACECR Institute of Higher Education (Isfahan Branch), Isfahan, Iran. [Vakilian,M] Department of Cell Regeneration and Advanced Therapies, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain. [Peymani,M] Department of Biology, Faculty of Basic Sciences, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran. [Peymani,M; Seyed Forootan,F; Nasr Esfahani,MH; Ghaedi,K] Department of Cellular Biotechnology, Cell Science Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. [Seyed Forootan,F] Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran. [Ghaedi,K] Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Keywords: Colorectal cancer;EGFR;MAPK;Notch;TGF-B;Neoplasias colorrectales;Genes erbB-1;Proteína quinasa 1 activada por mitógenos;Mitogen-Activated Protein Kinase 1;Receptores Notch;Factor de crecimiento transformador beta
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::Mitogen-Activated Protein Kinases
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::TGF-beta Superfamily Proteins
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors::Receptors, Notch
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Genes, Neoplasm::Oncogenes::Proto-Oncogenes::Genes, erbB::Genes, erbB-1
Issue Date: 2-Dec-2019
Publisher: BioMed Central Ltd.
Citation: Koveitypour Z, Panahi F, Vakilian M, Peymani M, Seyed Forootan F, Nasr Esfahani MH, et al. Signaling pathways involved in colorectal cancer progression. Cell Biosci. 2019 Dec 2;9:97.
Abstract: Colorectal cancer (CRC) is the fourth leading cause of the worldwide cancer mortality. Different molecular mechanisms have been attributed to the development and progress of CRC. In this review, we will focus on the mitogen-activated protein kinase (MAPK) cascades downstream of the epidermal growth factor receptor (EGFR), Notch, PI3K/AKT pathway, transforming growth factor-β (TGF-β), and Wnt signaling pathways. Various mutations in the components of these signaling pathways have been linked to the development of CRC. Accordingly, numerous efforts have been carried out to target the signaling pathways to develop novel therapeutic approaches. Herein, we review the signaling pathways involved in the incidence and progression of CRC, and the strategies for the therapy targeting components of signaling pathways in CRC.
metadata.dc.identifier.doi: 10.1186/s13578-019-0361-4
ISSN: 2045-3701 (Online)
Appears in Collections:01- Artículos - CABIMER. Centro Andaluz de Biología Molecular

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