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Title: Giant cell arteritis: is the clinical spectrum of the disease changing?
Authors: González-Gay, Miguel Á.
Ortego-Jurado, Miguel
Ercole, Liliana
Ortego-Centeno, Norberto
metadata.dc.contributor.authoraffiliation: [González-Gay,MÁ] Division of Rheumatology and Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqués de Valdecilla, Instituto de Investigación Marqués de Valdecilla, Santander, Spain. [González-Gay,MÁ] University of Cantabria, Santander, Spain. [González-Gay,MÁ] Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. [Ortego-Jurado,M] Emergency Health Services Agency-061 (EPES-061), Granada, Spain. [Ercole,L] Medical Department, Roche Pharma, Madrid, Spain. [Ortego-Centeno,N] Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria de Granada (IBS. GRANADA), Department of Internal Medicine, Professor of Medicine of the University of Granada, Granada, Spain.
Keywords: Giant-cell arteritis;Polymyalgia rheumatic;FDG-PET/CT;Arteritis de células gigantes;Polimialgia reumática;Fluorodeoxyglucose F18;Fluorodesoxiglucosa F18;Positron Emission Tomography Computed Tomography;Tomografía Computarizada por Tomografía de Emisión de Positrones
metadata.dc.subject.mesh: Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Biopsy
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Diseases::Nervous System Diseases::Autoimmune Diseases of the Nervous System::Vasculitis, Central Nervous System::Giant Cell Arteritis
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Surgical Procedures, Minimally Invasive::Magnetic Resonance Imaging, Interventional
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Polymyalgia Rheumatica
Positron Emission Tomography Computed Tomography
Medical Subject Headings::Anatomy::Cardiovascular System::Blood Vessels::Arteries::Cerebral Arteries::Temporal Arteries
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Deoxy Sugars::Deoxyglucose::Fluorodeoxyglucose F18
Issue Date: 29-Jul-2019
Publisher: BioMed Central Ltd.
Citation: González-Gay MÁ, Ortego-Jurado M, Ercole L, Ortego-Centeno N. Giant cell arteritis: is the clinical spectrum of the disease changing? BMC Geriatr. 2019 Jul 29;19(1):200.
Abstract: Background: Giant cell arteritis is a vasculitis of large and middle-sized arteries that affects patients aged over 50 years. It can show a typical clinical picture consisting of cranial manifestations but sometimes nonspecific symptoms and large-vessel involvement prevail. Prompt diagnosis and treatment is essential to avoid irreversible damage. Discussion: There has been an increasing knowledge on the occurrence of the disease without the typical cranial symptoms and its close relationship and overlap with polymyalgia rheumatica, and this may contribute to reduce the number of underdiagnosed patients. Although temporal artery biopsy is still the gold-standard and temporal artery ultrasonography is being widely used, newer imaging techniques (FDG-PET/TAC, MRI, CT) can be of valuable help to identify giant cell arteritis, in particular in those cases with a predominance of extracranial large-vessel manifestations. Conclusions: Giant cell arteritis is a more heterogeneous condition than previously thought. Awareness of all the potential clinical manifestations and judicious use of diagnostic tests may be an aid to avoid delayed detection and consequently ominous complications.
metadata.dc.identifier.doi: 10.1186/s12877-019-1225-9
ISSN: 1471-2318 (Online)
Appears in Collections:01- Artículos - Hospital San Cecilio
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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