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dc.contributor.authorCastellano-Castillo, Daniel-
dc.contributor.authorMorcillo, Sonsoles-
dc.contributor.authorCrujeiras, Ana B.-
dc.contributor.authorSánchez-Alcoholado, Lidia-
dc.contributor.authorClemente-Postigo, Mercedes-
dc.contributor.authorTorres, Esperanza-
dc.contributor.authorTinahones, Francisco José-
dc.contributor.authorMacias-Gonzalez, Manuel-
dc.identifier.citationCastellano-Castillo D, Morcillo S, Crujeiras AB, Sánchez-Alcoholado L, Clemente-Postigo M, Torres E, et al. Association between serum 25-hydroxyvitamin D and global DNA methylation in visceral adipose tissue from colorectal cancer patients. BMC Cancer. 2019 Jan 21;19(1):93.es_ES
dc.identifier.issn1471-2407 (Online)es_ES
dc.description.abstractBackground: Visceral adipose tissue (VAT) has been identified as the essential fat depot for pathogenetic theories that associateobesity and colon cancer. LINE-1 hypomethylation has been mostly detected in tumor colon tissue, but less is known about the epigenetic pattern in surrounding tissues. The aim was to analyze for the first time the potential relationship between serum vitamin D, obesity and global methylation (LINE-1) in the visceral adipose tissue (VAT) from patients with and without colorectal cancer. Methods: A total of 55 patients with colorectal cancer and 35 control subjects participated in the study. LINE-1 DNA methylation in VAT was measured by pyrosequencing. Serum 25(OH)D levels were determined by ELISA. Results: Cancer patients had lower levels of LINE-1 methylation in VAT compared with the control group. In the subjects with colorectal cancer, LINE-1 DNA methylation levels were associated positively with vitamin D levels (r = 0,463; p < 0.001) and negatively with BMI (r = − 0.334, p = 0.01) and HOMA insulin resistance index (r = − 0.348, p = 0.01). Serum vitamin D was the main variable explaining the LINE-1% variance in the cancer group (β = 0.460, p < 0.001). In a multivariate analysis, subjects with higher LINE-1 methylation values had lower risk of developing colorectal cancer (OR = 0.53; IC95% =0.28–0.99) compared with the control group. Conclusions: We showed for the first time an association between LINE-1 DNA methylation in VAT and vitamin D levels in subjects with colorectal cancer, highlighting the importance of VAT from cancer patients, which could be modified epigenetically compared to healthy subjects.es_ES
dc.description.sponsorshipThis study was supported by “Centros de Investigación En Red” (CIBER, CB06/03/0018) of the “Instituto de Salud Carlos III” (ISCIII), and grants from ISCIII (PI11/01661) and from Consejeria de Innovacion, Ciencia y Empresa de la Junta de Andalucia (PI11-CTS-8181). Co financed by the European Regional Development Fund (FEDER).es_ES
dc.format.extent7 p.es_ES
dc.publisherBioMed Central Ltd.es_ES
dc.relation.ispartofBMC Canceres_ES
dc.subjectColorectal canceres_ES
dc.subjectGlobal DNA methylationes_ES
dc.subjectVitamin Des_ES
dc.subjectNeoplasias colorrectaleses_ES
dc.subjectMetilación de ADNes_ES
dc.subjectEpigénesis genéticaes_ES
dc.subjectVitamina Des_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasmses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Methylationes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Sequence Analysis::Sequence Analysis, DNAes_ES
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesityes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Secosteroids::Vitamin Des_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Interspersed Repetitive Sequences::Retroelements::Long Interspersed Nucleotide Elementses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Molecular Probe Techniques::Immunoassay::Immunoenzyme Techniques::Enzyme-Linked Immunosorbent Assayes_ES
dc.subject.meshMedical Subject Headings::Persons::Persons::Age Groups::Adult::Agedes_ES
dc.subject.meshMedical Subject Headings::Check Tags::Malees_ES
dc.subject.meshMedical Subject Headings::Check Tags::Femalees_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Abdominal Fat::Intra-Abdominal Fates_ES
dc.titleAssociation between serum 25-hydroxyvitamin D and global DNA methylation in visceral adipose tissue from colorectal cancer patientses_ES
dc.rights.accessRightsAcceso abiertoes_ES
dc.contributor.authoraffiliation[Castellano-Castillo,D; Morcillo,S; Sánchez-Alcoholado,L; Clemente-Postigo,M; Tinahones,FJ; Macias-Gonzalez,M] Unidad de Gestión Clínica Endocrinología y Nutrición. Instituto de Investigación Biomédica de Málaga (IBIMA), Complejo Hospitalario de Málaga (Virgen de la Victoria) Málaga (Spain). CIBER Fisiopatología de la Obesidad y Nutrición (CB06/03), Málaga, Spain. [Crujeiras,AB] Epigenomics in Endocrinology and Nutrition Group. Instituto de Investigacion Sanitaria (IDIS), Complejo Hospitalario Universitario de Santiago (CHUS) and CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Málaga, Spain. [Torres,E] Unidad de Gestión Clínica de Oncología Intercentros Hospital Universitario Virgen de la Victoria, Málaga, Spain.es_ES
dc.type.subtypeArtículo originales_ES
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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