Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3195
Title: In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network
Authors: Esteva-Socias, Margalida
Artiga, María-Jesús
Bahamonde, Olga
Belar, Oihana
Bermudo, Raquel
Castro, Erika
Escámez, Teresa
Máximo, Fraga
Jauregui-Mosquera, Laura
Novoa, Isabel
Peiró-Chova, Lorena
Rejón, Juan-David
Ruiz-Miró, María
Vieiro-Balo, Paula
Villar-Campo, Virginia
Zazo, Sandra
Rábano, Alberto
Villena, Cristina
metadata.dc.contributor.authoraffiliation: [Esteva-Socias;M; Villena,C] Centro de Investigación Biomédica en Red Respiratory Diseases (CIBERES), Plataforma Biobanco Pulmonar CIBERES, Hospital Universitari Son Espases, Palma, Spain. [Esteva-Socias;M; Villena,C] Grupo de Inflamación, reparación y cáncer en enfermedades respiratorias, Institut d’Investigació Sanitària de les Illes Balears (IdISBa), Hospital Universitari Son Espases, Palma, Spain. [Artiga,MJ] CNIO Biobank, Spanish National Cancer Centre (CNIO), Madrid, Spain. [Bahamonde,O; Peiró-Chova,L] INCLIVA Biobank, Valencia, Spain. [Belar,O; Castro,E] Basque Foundation for Health Innovation and Research, Basque Biobank, Barakaldo, Spain. [Bermudo,R] Hospital Clínic-IDIBAPS Biobank, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. [Escámez,T] IMIB Biobank, Instituto Murciano de Investigación Biosanitaria, Murcia, Spain. [Fraga,M] Depto. de Ciencias Forenses, Anatomía Patolóxica, Xinecología e Obstetricia, e Pediatría, Facultade de Medicina, Universidade de Santiago de Compostela (USC), Santiago, Spain. [Fraga,M; Vieiro-Balo,P] Biobanco Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago, Spain. [Jauregui-Mosquera,L; Villar-Campo,V] University of Navarra’s Biobank-IdiSNA, Pamplona, Spain. [Novoa,I] Vall d’Hebron University Hospital Biobank, Vall d’Hebron Hospital Research Institute, Barcelona, Spain. [Rejón,JD] Biobanco del Sistema Sanitario Público de Andalucía, Granada, Spain. [Ruiz-Miró,M] IRBLleida Biobank, Instituto de Investigaciones Biomédica de Lleida-Fundación Dr. Pifarre, Lérida, Spain. [Zazo,S] Department of Pathology, IIS-Fundación Jiménez Díaz, Madrid, Spain. [Rábano,A] Banco de Tejidos, Fundación CIEN, Instituto de Salud Carlos III, Madrid, Spain.
Keywords: Quality;Pre-analytical variables;Biobank;Tissue;Biospecimen science;Quality control;Control de calidad;Technology assessment, biomedical;Evaluación de la tecnología biomédica;Banco de tejidos;Tissue preservation;Conservación de tejido;Tejidos
metadata.dc.subject.mesh: Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Biological Specimen Banks
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Science::Research::Biomedical Research
Medical Subject Headings::Disciplines and Occupations::Health Occupations::Evidence-Based Practice::Evidence-Based Medicine
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Histocytological Preparation Techniques::Tissue Embedding
Medical Subject Headings::Health Care::Health Services Administration::Quality of Health Care::Quality Assurance, Health Care
Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Histocytological Preparation Techniques::Tissue Preservation::Tissue Fixation
Issue Date: 12-Nov-2019
Publisher: BioMed Central Ltd.
Citation: Esteva-Socias M, Artiga MJ, Bahamonde O, Belar O, Bermudo R, Castro E, et al. In search of an evidence-based strategy for quality assessment of human tissue samples: report of the tissue Biospecimen Research Working Group of the Spanish Biobank Network. J Transl Med. 2019 Nov 12;17(1):370.
Abstract: The purpose of the present work is to underline the importance of obtaining a standardized procedure to ensure and evaluate both clinical and research usability of human tissue samples. The study, which was carried out by the Biospecimen Science Working Group of the Spanish Biobank Network, is based on a general overview of the current situation about quality assurance in human tissue biospecimens. It was conducted an exhaustive review of the analytical techniques used to evaluate the quality of human tissue samples over the past 30 years, as well as their reference values if they were published, and classified them according to the biomolecules evaluated: (i) DNA, (ii) RNA, and (iii) soluble or/and fixed proteins for immunochemistry. More than 130 publications released between 1989 and 2019 were analysed, most of them reporting results focused on the analysis of tumour and biopsy samples. A quality assessment proposal with an algorithm has been developed for both frozen tissue samples and formalin-fixed paraffin-embedded (FFPE) samples, according to the expected quality of sample based on the available pre-analytical information and the experience of the participants in the Working Group. The high heterogeneity of human tissue samples and the wide number of pre-analytic factors associated to quality of samples makes it very difficult to harmonize the quality criteria. However, the proposed method to assess human tissue sample integrity and antigenicity will not only help to evaluate whether stored human tissue samples fit for the purpose of biomarker development, but will also allow to perform further studies, such as assessing the impact of different pre-analytical factors on very well characterized samples or evaluating the readjustment of tissue sample collection, processing and storing procedures. By ensuring the quality of the samples used on research, the reproducibility of scientific results will be guaranteed.
URI: http://hdl.handle.net/10668/3195
metadata.dc.relation.publisherversion: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-019-2124-8
metadata.dc.identifier.doi: 10.1186/s12967-019-2124-8
ISSN: 1479-5876 (Online)
Appears in Collections:01- Artículos - Biobanco del Sistema Sanitario Público de Andalucía

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