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Title: Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance.
Authors: Sáez, María E
Smani, Tarik
Ramírez-Lorca, Reposo
Díaz, Ignacio
Serrano-Ríos, Manuel
Ruiz, Agustín
Ordoñez, Antonio
metadata.dc.contributor.authoraffiliation: [Sáez,ME; Ramírez-Lorca,R; Ruiz,A]Department of Structural Genomics, Neocodex, Sevilla, Spain.[Smani,T; Díaz,I; Ordoñez,A] Grupo de Fisiopatología Cardiovascular. Instituto de Biomedicina de Sevilla. Hospital Universitario Virgen de Rocío. CSIC. Universidad de Sevilla, Sevilla, Spain. [Serrano-Ríos,M] Diabetes Research Laboratory, Biomedical Research Foundation, University Hospital Clínico San Carlos, Madrid, Spain Fisiopatología Cardiovascular
Keywords: Urotensinas;Resistencia a la insulina;Polimorfismo genético
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Urotensins
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Issue Date: 29-Apr-2011
Publisher: PLoS
Citation: Sáez ME, Smani T, Ramírez-Lorca R, Díaz I, Serrano-Ríos M, Ruiz A, et al. Association Analysis of Urotensin II Gene (UTS2) and Flanking Regions with Biochemical Parameters Related to Insulin Resistance.PLoS ONE 2011; 6(4): e19327
Abstract: Background. Urotensin II (UII) is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR) known as GPR14 or urotensin receptor (UTR). UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release. Objective. Given the reported role of UII in insulin secretion, we have performed a genetic association analysis of the UTS2 gene and flanking regions with biochemical parameters related to insulin resistance (fasting glucose, glucose 2 hours after a glucose overload, fasting insulin and insulin resistance estimated as HOMA). Results and Conclusions. We have identified several polymorphisms associated with the analysed clinical traits, not only at the UTS2 gene, but also in thePER3 gene, located upstream from UTS2. Our results are compatible with a role for UII in glucose homeostasis and diabetes although we cannot rule out the possibility that PER3 gene may underlie the reported associations.
metadata.dc.identifier.doi: 10.1371/journal.pone.0019327
ISSN: 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Virgen del Rocío

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