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Title: Magnetic Nanoparticles as MRI Contrast Agents
Authors: Avasthi, Ashish
Caro, Carlos
Pozo-Torres, Esther
Pernia Leal, Manuel
García-Martín, María Luisa
metadata.dc.contributor.authoraffiliation: [Avasthi,A; Caro,C; García-Martín,ML] BIONAND - Centro Andaluz de Nanomedicina y Biotecnología, Junta de Andalucía-Universidad de Málaga, Málaga, Spain. [Pozo-Torres,E; Pernia Leal,M] Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Seville, Spain. [García-Martín,ML] Networking Research Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Málaga, Spain.
Keywords: Magnetic nanoparticles;Iron oxide nanoparticles;Magnetic resonance imaging;Cancer;Diagnosis;Nanopartículas magnéticas de óxido de hierro;Imagen por resonancia magnética;Neoplasias;Diagnóstico
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Diagnostic Uses of Chemicals::Contrast Media
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Imaging::Magnetic Resonance Imaging
Medical Subject Headings::Technology and Food and Beverages::Technology, Industry, and Agriculture::Manufactured Materials::Nanostructures::Nanoparticles::Metal Nanoparticles::Magnetite Nanoparticles
Medical Subject Headings::Diseases::Neoplasms
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis
Issue Date: 7-May-2020
Publisher: SpringerNature
Citation: Avasthi A, Caro C, Pozo-Torres E, Leal MP, García-Martín ML. Magnetic Nanoparticles as MRI Contrast Agents. Top Curr Chem (Cham). 2020 May 7;378(3):40. Erratum in: Top Curr Chem (Cham). 2021 Jun 14;379(4):30.
Abstract: Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to conventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excellent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the possibility of carrying out molecular MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocompatible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.
metadata.dc.identifier.doi: 10.1007/s41061-020-00302-w
ISSN: 2365-0869 (Print)
2364-8961 (Online)
Appears in Collections:01- Artículos - BIONAND - Centro Andaluz de Nanomedicina y Biotecnología

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