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1. Repositorio Salud Andalucía
2. 05- Centros e institutos de investigación
3. ibsGRANADA. Instituto de Investigación Biosanitaria de Granada
4. 01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

Title:	A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial
Authors:	Rodríguez-Rubio, Miguel Figueira, Juan Carlos Acuña-Castroviejo, Darío Borobia, Alberto M. Escames, Germaine de la Oliva, Pedro
metadata.dc.contributor.authoraffiliation:	[Rodríguez-Rubio,M; de la Oliva,P] Pediatric Intensive Care Department, Hospital Universitario La Paz, Madrid, Spain. [Rodríguez-Rubio,M; de la Oliva,P] Department of Pediatrics, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain. [Figueira,JC] Intensive Care Medicine Department, Hospital Universitario La Paz, Madrid, Spain. [Acuña-Castroviejo,D; Escames,G] Department of Physiology, Faculty of Medicine, Biomedical Research Center, Health Science Technology Park, University of Granada, Granada, Spain. [Acuña-Castroviejo,D; Escames,G] CIBERfes, Ibs Granada, Granada, Spain. [Acuña-Castroviejo,D] Clinical Laboratories, San Cecilio University Hospital, Granada, Spain. [Borobia,AM] Clinical Pharmacology Department, Clinical Trial Unit, Hospital Universitario La Paz – IdiPAZ, Madrid, Spain. [Borobia,AM] School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
Keywords:	COVID-19;Randomized controlled trial;Protocol;Melatonin;Treatment;Intensive care;ARDS;Inflammation;Infecciones por coronavirus;Ensayo clínico controlado aleatorio;Protocolo de ensayo clínico;Melatonina;Terapéutica;Unidades de cuidados intensivos;Síndrome de dificultad respiratoria del adulto;Inflamación
metadata.dc.subject.mesh:	Medical Subject Headings::Diseases::Respiratory Tract Diseases::Respiration Disorders::Respiratory Distress Syndrome, Adult Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Intravenous Medical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Double-Blind Method Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Units Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization::Length of Stay Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Melatonin Medical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemics Medical Subject Headings::Diseases::Virus Diseases::Pneumonia, Viral Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic
Issue Date:	5-Aug-2020
Publisher:	BioMed Central
Citation:	Rodríguez-Rubio M, Figueira JC, Acuña-Castroviejo D, Borobia AM, Escames G, de la Oliva P. A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial. Trials. 2020 Aug 5;21(1):699.
URI:	https://www.repositoriosalud.es/10668/10668/3393
metadata.dc.relation.publisherversion:	https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04632-4
metadata.dc.identifier.doi:	10.1186/s13063-020-04632-4
ISSN:	1745-6215 (Online)
Appears in Collections:	01- Artículos - Hospital San Cecilio 01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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