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Title: Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude
Authors: Benavente, Cristina
León, Josefa
Feriche, Belén
Schoenfeld, Brad J.
Bonitch-Góngora, Juan
Almeida, Filipa
Pérez-Regalado, Sergio
Padial, Paulino
metadata.dc.contributor.authoraffiliation: [Benavente,C; Feriche,B; Bonitch-Góngora,J; Almeida,F; Pérez-Regalado,S; Padial,P] Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain. [León,J] Clinical Management Unit of Digestive System, San Cecilio Hospital, ibs.GRANADA, Granada, Spain. [Schoenfeld,BJ] Department of Health Sciences, CUNY Lehman College, Bronx, NY, USA.
Keywords: Strength;Cytokines;miRNA;Terrestrial altitude;Hypoxia;Entrenamiento de fuerza;Citocinas;MicroARNs;Hipoxia
metadata.dc.subject.mesh: Medical Subject Headings::Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environment::Altitude
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Pregnanes::Pregnenes::Pregnenediones::Hydrocortisone
Medical Subject Headings::Persons::Persons::Men::Nurses, Male
Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Androstanes::Androstenes::Androstenols::Testosterone::Testosterone Propionate
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Growth Hormone::Human Growth Hormone
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Physical Therapy Modalities::Exercise Therapy::Resistance Training
Medical Subject Headings::Anatomy::Musculoskeletal System::Muscles::Muscle, Skeletal
Issue Date: 16-Apr-2021
Publisher: MDPI AG
Citation: Benavente C, León J, Feriche B, Schoenfeld BJ, Bonitch-Góngora J, Almeida F, et al. Hormonal and Inflammatory Responses to Hypertrophy-Oriented Resistance Training at Acute Moderate Altitude. International Journal of Environmental Research and Public Health. 2021;18(8):4233.
Abstract: This study investigated the effect of a traditional hypertrophy-oriented resistance training (RT) session at acute terrestrial hypoxia on inflammatory, hormonal, and the expression of miR-378 responses associated with muscular gains. In a counterbalanced fashion, 13 resistance trained males completed a hypertrophic RT session at both moderate-altitude (H; 2320 m asl) and under normoxic conditions (N; <700 m asl). Venous blood samples were taken before and throughout the 30 min post-exercise period for determination of cytokines (IL6, IL10, TNFα), hormones (growth hormone [GH], cortisol [C], testosterone), and miR-378. Both exercise conditions stimulated GH and C release, while miR-378, testosterone, and inflammatory responses remained near basal conditions. At H, the RT session produced a moderate to large but nonsignificant increase in the absolute peak values of the studied cytokines. miR-378 revealed a moderate association with GH (r = 0.65; p = 0.026 and r = -0.59; p = 0.051 in N and H, respectively) and C (r = 0.61; p = 0.035 and r = 0.75; p = 0.005 in N and H, respectively). The results suggest that a RT session at H does not differentially affect the hormonal, inflammatory, and miR-378 responses compared to N. However, the standardized mean difference detected values in the cytokines suggest an intensification of the inflammatory response in H that should be further investigated.
metadata.dc.identifier.doi: 10.3390/ijerph18084233
ISSN: 1661-7827 (Print)
1660-4601 (Online)
Appears in Collections:01- Artículos - Hospital San Cecilio
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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