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Title: Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease
Authors: Puentes-Pardo, Jose D.
Moreno-SanJuan, Sara
Carazo, Ángel
León, Josefa
metadata.dc.contributor.authoraffiliation: [Puentes-Pardo,JD; León,J] Research Unit, Instituto de Investigacion Biosanitaria de Granada, ibs.GRANADA, Granada, Spain. [Puentes-Pardo,JD] Department of Pharmacology, Faculty of Pharmacy, University of Granada, Granada, Spain. [Moreno-SanJuan,S] Cytometry and Microscopy Research Service, Instituto de Investigacion Biosanitaria de Granada, ibs.GRANADA, Granada, Spain. [Carazo,A] Genomic Research Service, Instituto de Investigacion Biosanitaria de Granada, ibs.GRANADA, Granada, Spain. [León,J] Clinical Management Unit of Digestive Disease, San Cecilio University Hospital, Granada, Spain.
Keywords: Heme oxygenase;Gastrointestinal tract;Cancer;Diabetes;Pancreatitis;Inflammatory bowel disease;Peptic ulcer disease;Fatty liver disease;Ferroptosis;Hemo-oxigenasa 1;Tracto gastrointestinal;Neoplasias;Enfermedades inflamatorias del intestino;Úlcera péptica;Enfermedad del hígado graso no alcohólico;Diabetes mellitus
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxygenases::Mixed Function Oxygenases::Heme Oxygenase (Decyclizing)::Heme Oxygenase-1
Medical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract
Medical Subject Headings::Diseases::Neoplasms
Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus
Medical Subject Headings::Diseases::Digestive System Diseases::Pancreatic Diseases::Pancreatitis
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Inflammatory Bowel Diseases
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Peptic Ulcer
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Issue Date: 2-Dec-2020
Publisher: MDPI
Citation: Puentes-Pardo JD, Moreno-SanJuan S, Carazo Á, León J. Heme Oxygenase-1 in Gastrointestinal Tract Health and Disease. Antioxidants (Basel). 2020 Dec 2;9(12):1214
Abstract: Heme oxygenase 1 (HO-1) is the rate-limiting enzyme of heme oxidative degradation, generating carbon monoxide (CO), free iron, and biliverdin. HO-1, a stress inducible enzyme, is considered as an anti-oxidative and cytoprotective agent. As many studies suggest, HO-1 is highly expressed in the gastrointestinal tract where it is involved in the response to inflammatory processes, which may lead to several diseases such as pancreatitis, diabetes, fatty liver disease, inflammatory bowel disease, and cancer. In this review, we highlight the pivotal role of HO-1 and its downstream effectors in the development of disorders and their beneficial effects on the maintenance of the gastrointestinal tract health. We also examine clinical trials involving the therapeutic targets derived from HO-1 system for the most common diseases of the digestive system.
metadata.dc.identifier.doi: 10.3390/antiox9121214
ISSN: 2076-3921 (Online)
Appears in Collections:01- Artículos - Hospital San Cecilio
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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