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http://hdl.handle.net/10668/3546| Title: | The Epigenetics of Glioma Stem Cells: A Brief Overview |
| Authors: | Valor, Luis M. Hervás-Corpión, Irati |
| metadata.dc.contributor.authoraffiliation: | [Valor,LM; Hervás-Corpión,I] Unidad de Investigación, Hospital Universitario Puerta del Mar, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain. |
| Keywords: | Glioblastoma;Histone;DNA;Methylation;Acetylation;Polycomb;H3.3;HDACi;Histonas;ADN;Metilación;Acetilación |
| metadata.dc.subject.mesh: | Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Nerve Tissue::Neuroectodermal Tumors::Neoplasms, Neuroepithelial::Glioma::Astrocytoma::Glioblastoma Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells Medical Subject Headings::Anatomy::Cells::Stem Cells::Neural Stem Cells Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Methylation Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Acylation::Acetylation |
| Issue Date: | 2-Dec-2020 |
| Publisher: | Frontiers |
| Citation: | Valor LM, Hervás-Corpión I. The Epigenetics of Glioma Stem Cells: A Brief Overview. Front Oncol. 2020 Dec 2;10:602378 |
| Abstract: | Glioma stem cells (GSCs) are crucial in the formation, perpetuation and recurrence of glioblastomas (GBs) due to their self-renewal and proliferation properties. Although GSCs share cellular and molecular characteristics with neural stem cells (NSCs), GSCs show unique transcriptional and epigenetic features that may explain their relevant role in GB and may constitute druggable targets for novel therapeutic approaches. In this review, we will summarize the most important findings in GSCs concerning epigenetic-dependent mechanisms. |
| URI: | http://hdl.handle.net/10668/3546 |
| metadata.dc.relation.publisherversion: | https://www.frontiersin.org/articles/10.3389/fonc.2020.602378/full |
| metadata.dc.identifier.doi: | 10.3389/fonc.2020.602378 |
| ISSN: | 2234-943X (Online) |
| Appears in Collections: | 01 - Artículos - INiBICA. Instituto de Investigación e Innovación Biomédica de Cádiz 01- Artículos - Hospital Puerta del Mar |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Valor_TheEpigeneticsOf.pdf | Revisión | 566,23 kB | Adobe PDF | View/Open |
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