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Title: The Epigenetics of Glioma Stem Cells: A Brief Overview
Authors: Valor, Luis M.
Hervás-Corpión, Irati
metadata.dc.contributor.authoraffiliation: [Valor,LM; Hervás-Corpión,I] Unidad de Investigación, Hospital Universitario Puerta del Mar, Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Cádiz, Spain.
Keywords: Glioblastoma;Histone;DNA;Methylation;Acetylation;Polycomb;H3.3;HDACi;Histonas;ADN;Metilación;Acetilación
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Nerve Tissue::Neuroectodermal Tumors::Neoplasms, Neuroepithelial::Glioma::Astrocytoma::Glioblastoma
Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells
Medical Subject Headings::Anatomy::Cells::Stem Cells::Neural Stem Cells
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Methylation
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Acylation::Acetylation
Issue Date: 2-Dec-2020
Publisher: Frontiers
Citation: Valor LM, Hervás-Corpión I. The Epigenetics of Glioma Stem Cells: A Brief Overview. Front Oncol. 2020 Dec 2;10:602378
Abstract: Glioma stem cells (GSCs) are crucial in the formation, perpetuation and recurrence of glioblastomas (GBs) due to their self-renewal and proliferation properties. Although GSCs share cellular and molecular characteristics with neural stem cells (NSCs), GSCs show unique transcriptional and epigenetic features that may explain their relevant role in GB and may constitute druggable targets for novel therapeutic approaches. In this review, we will summarize the most important findings in GSCs concerning epigenetic-dependent mechanisms.
metadata.dc.identifier.doi: 10.3389/fonc.2020.602378
ISSN: 2234-943X (Online)
Appears in Collections:01 - Artículos - INiBICA. Instituto de Investigación e Innovación Biomédica de Cádiz
01- Artículos - Hospital Puerta del Mar

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