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http://hdl.handle.net/10668/3549| Title: | MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair |
| Authors: | Rivero, Sabrina Rodríguez-Real, Guillermo Marín, Inés Huertas, Pablo |
| metadata.dc.contributor.authoraffiliation: | [Rivero,S] Department of Normal and Pathological Histology and Cytology, University of Seville School of Medicine, Spain. [Rivero,S; Rodríguez-Real,G; Marín,I; Huertas,P] Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Spain. [Rodríguez-Real,G; Huertas,P] Department of Genetics, University of Seville, Spain. |
| Keywords: | DNA repair;DNA-end resection;MRGBP;TIP60;Recombination;Reparación del ADN;Lisina acetiltransferasa 5;Recombinación genética |
| metadata.dc.subject.mesh: | Medical Subject Headings::Anatomy::Cells::Cells, Cultured::Cell Line::Cell Line, Tumor Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage::DNA Breaks::DNA Breaks, Double-Stranded Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repair::DNA End-Joining Repair Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::Acetyltransferases::Histone Acetyltransferases Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic::Homologous Recombination::Recombinational DNA Repair Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::DNA Repair Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Down-Regulation |
| Issue Date: | 21-Dec-2021 |
| Publisher: | John Wiley & Sons Ltd. |
| Citation: | Rivero S, Rodríguez-Real G, Marín I, Huertas P. MRGBP, a member of the NuA4 complex, inhibits DNA double-strand break repair. FEBS Open Bio. 2021 11: 622-632 |
| Abstract: | The repair of DNA breaks takes place in the context of chromatin and thus involves the activity of chromatin remodelers. The nucleosome acetyltransferase of H4 (NuA4) remodeler complex enables DNA break repair by relaxing flanking chromatin. Here, we show that MRG domain binding protein (MRGBP), a member of this complex, acts as a general inhibitor of DNA double-strand break repair. Upon its downregulation, repair is generally increased. This is particularly evident for the stimulation of early events of homologous recombination. Thus, MRGBP has an opposing role to the main catalytic subunits of the NuA4 complex. Our data suggest that MRGBP acts by limiting the activity of this complex in DNA repair, specifically by narrowing the extent of DNA-end resection. |
| URI: | http://hdl.handle.net/10668/3549 |
| metadata.dc.relation.publisherversion: | https://febs-onlinelibrary-wiley-com.bvsspa.idm.oclc.org/doi/full/10.1002/2211-5463.13071 |
| metadata.dc.identifier.doi: | 10.1002/2211-5463.13071 |
| ISSN: | 2211-5463 (Online) |
| Appears in Collections: | 01- Artículos - CABIMER. Centro Andaluz de Biología Molecular |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Rivero_MRGBP.pdf | Artículo original | 1,53 MB | Adobe PDF | View/Open |
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