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http://hdl.handle.net/10668/3568| Title: | Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage |
| Authors: | Ortega, Pedro García-Pichardo, Desiré San Martin-Alonso, Marta Rondón, Ana G. Gómez-González, Belén Aguilera, Andrés |
| metadata.dc.contributor.authoraffiliation: | [Ortega,P; García-Pichardo,D; San Martin-Alonso,M; Rondón, AG; Gómez-González,B; Aguilera,A] Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Seville, Spain. |
| Keywords: | Chromatin;DNA replication;Recombination;Histone mutants;Cromatina;Replicación del ADN;Recombinación genética;Histonas;Mutación |
| metadata.dc.subject.mesh: | Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Histones Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Repair Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Replication Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutation Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Chromosome Structures::Chromatin |
| Issue Date: | 24-Apr-2020 |
| Publisher: | Shared Science Publishers |
| Citation: | Ortega P, García-Pichardo D, San Martin-Alonso M, Rondón AG, Gómez-González B, Aguilera A. Histone H3E73Q and H4E53A mutations cause recombinogenic DNA damage. Microb Cell. 2020 Apr 24;7(7):190-198. |
| Abstract: | The stability and function of eukaryotic genomes is closely linked to histones and to chromatin structure. The state of the chromatin not only affects the probability of DNA to undergo damage but also DNA repair. DNA damage can result in genetic alterations and subsequent development of cancer and other genetic diseases. Here, we identified two mutations in conserved residues of histone H3 and histone H4 (H3E73Q and H4E53A) that increase recombinogenic DNA damage. Our results suggest that the accumulation of DNA damage in these histone mutants is largely independent on transcription and might arise as a consequence of problems occurring during DNA replication. This study uncovers the relevance of H3E73 and H4E53 residues in the protection of genome integrity. |
| URI: | http://hdl.handle.net/10668/3568 |
| metadata.dc.relation.publisherversion: | http://microbialcell.com/researcharticles/2020a-ortega-microbial-cell/ |
| metadata.dc.identifier.doi: | 10.15698/mic2020.07.723 |
| ISSN: | 2311-2638 (Online) |
| Appears in Collections: | 01- Artículos - CABIMER. Centro Andaluz de Biología Molecular |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Ortega_HistoneH3E73Q.pdf | Artículo publicado | 1,05 MB | Adobe PDF | View/Open |
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