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Title: Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment
Authors: López de Andrés, Julia
Griñán-Lisón, Carmen
Jiménez, Gema
Marchal, Juan Antonio
metadata.dc.contributor.authoraffiliation: [López de Andrés,J; Griñán-Lisón,C; Jiménez,G; Marchal,JA] Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research (CIBM), University of Granada,Granada, Spain. [López de Andrés,J; Griñán-Lisón,C; Jiménez,G; Marchal,JA] Instituto de Investigación Biosanitaria Ibs.GRANADA, University Hospitals of Granada-University of Granada, Granada, Spain. [López de Andrés,J; Griñán-Lisón,C; Jiménez,G; Marchal,JA] Excellence Research Unit “Modeling Nature” (MNat), University of Granada, Granada, Spain. [Jiménez,G] Department of Health Sciences, University of Jaén, Jaén, Spain. [Marchal,JA] Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain.
Keywords: Cancer stem cells;Tumor microenvironment;Secretome;Growth factors;Interleukins;miRNAs;Exosomes;Células madre neoplásicas;Microambiente tumoral;Factores de crecimiento endotelial vascular;Interleucinas;MicroARNs;Péptidos y proteínas de señalización intercelular
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Cytoplasmic Vesicles::Transport Vesicles::Exosomes
Medical Subject Headings::Anatomy::Cells::Cellular Structures::Extracellular Space::Extracellular Matrix
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Cytokines::Interleukins
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Antisense::MicroRNAs
Medical Subject Headings::Diseases::Neoplasms
Medical Subject Headings::Anatomy::Cells::Stem Cells::Neoplastic Stem Cells
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Metaplasia::Neovascularization, Pathologic
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
Issue Date: 15-Oct-2020
Publisher: Springer Nature
Citation: López de Andrés J, Griñán-Lisón C, Jiménez G, Marchal JA. Cancer stem cell secretome in the tumor microenvironment: a key point for an effective personalized cancer treatment. J Hematol Oncol. 2020 Oct 15;13(1):136
Abstract: Cancer stem cells (CSCs) represent a tumor subpopulation responsible for tumor metastasis and resistance to chemo- and radiotherapy, ultimately leading to tumor relapse. As a consequence, the detection and eradication of this cell subpopulation represent a current challenge in oncology medicine. CSC phenotype is dependent on the tumor microenvironment (TME), which involves stem and differentiated tumor cells, as well as different cell types, such as mesenchymal stem cells, endothelial cells, fibroblasts and cells of the immune system, in addition to the extracellular matrix (ECM), different in composition to the ECM in healthy tissues. CSCs regulate multiple cancer hallmarks through the interaction with cells and ECM in their environment by secreting extracellular vesicles including exosomes, and soluble factors such as interleukins, cytokines, growth factors and other metabolites to the TME. Through these factors, CSCs generate and activate their own tumor niche by recruiting stromal cells and modulate angiogenesis, metastasis, resistance to antitumor treatments and their own maintenance by the secretion of different factors such as IL-6, VEGF and TGF-ß. Due to the strong influence of the CSC secretome on disease development, the new antitumor therapies focus on targeting these communication networks to eradicate the tumor and prevent metastasis, tumor relapse and drug resistance. This review summarizes for the first time the main components of the CSC secretome and how they mediate different tumor processes. Lastly, the relevance of the CSC secretome in the development of more precise and personalized antitumor therapies is discussed.
metadata.dc.identifier.doi: 10.1186/s13045-020-00966-3
ISSN: 1756-8722 (Online)
Appears in Collections:01- Artículos - Complejo Hospitalario Universitario de Granada
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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