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Title: Thyroid hormones in diabetes, cancer, and aging
Authors: Gauthier, Benoit R.
Sola-García, Alejandro
Cáliz-Molina, María Ángeles
Lorenzo, Petra Isabel
Cobo-Vuilleumier, Nadia
Capilla-González, Vivian
Martin-Montalvo, Alejandro
metadata.dc.contributor.authoraffiliation: [Gauthier,BR; Sola-García,A; Cáliz-Molina,MA; Lorenzo,PI; Cobo-Vuilleumier;N; Capilla-González,V; Martin-Montalvo,A] Department of Cell Therapy and Regeneration, Andalusian Center for Molecular Biology and Regenerative Medicine-CABIMER, Junta de Andalucía- University of Pablo de Olavide-University of Seville-CSIC, Seville, Spain. [Gauthier,BR] Biomedical Research Network on Diabetes and Related Metabolic Diseases-CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain.
Keywords: Cancer;Diabetes;Health span;Hyperthyroidism;Hypothyroidism;Life span;Thyroid hormones;Neoplasias;Diabetes mellitus;Hipertiroidismo;Hipotiroidismo;Longevidad;Hormonas tiroideas
metadata.dc.subject.mesh: Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Aging
Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Neoplasms
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
Medical Subject Headings::Anatomy::Endocrine System::Endocrine Glands::Thyroid Gland
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Thyroid Hormones
Medical Subject Headings::Diseases::Endocrine System Diseases::Thyroid Diseases::Hypothyroidism
Medical Subject Headings::Diseases::Endocrine System Diseases::Thyroid Diseases::Hyperthyroidism
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Longevity
Issue Date: 2020
Publisher: Anatomical Society and John Wiley & Sons Ltd
Citation: Gauthier BR, Sola-García A, Cáliz-Molina MÁ, Lorenzo PI, Cobo-Vuilleumier N, Capilla-González V, et al. Thyroid hormones in diabetes, cancer, and aging. Aging Cell. 2020 Nov;19(11):e13260
Abstract: Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and human research have determined that thyroid hormones modulate cellular processes relevant for aging and for the majority of age-related diseases. While several studies have associated mild reductions on thyroid hormone function with exceptional longevity in animals and humans, alterations in thyroid hormones are serious medical conditions associated with unhealthy aging and premature death. Moreover, both hyperthyroidism and hypothyroidism have been associated with the development of certain types of diabetes and cancers, indicating a great complexity of the molecular mechanisms controlled by thyroid hormones. In this review, we describe the latest findings in thyroid hormone research in the field of aging, diabetes, and cancer, with a special focus on hepatocellular carcinomas. While aging studies indicate that the direct modulation of thyroid hormones is not a viable strategy to promote healthy aging or longevity and the development of thyromimetics is challenging due to inefficacy and potential toxicity, we argue that interventions based on the use of modulators of thyroid hormone function might provide therapeutic benefit in certain types of diabetes and cancers.
metadata.dc.identifier.doi: 10.1111/acel.13260
ISSN: 1474-9726 (Online)
Appears in Collections:01- Artículos - CABIMER. Centro Andaluz de Biología Molecular

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