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Title: Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution?
Authors: de Ceglia, Marialuisa
Decara, Juan
Gaetani, Silvana
Rodríguez de Fonseca, Fernando
metadata.dc.contributor.authoraffiliation: [de Ceglia,M; Decara,J; Rodríguez de Fonseca,F] UGC Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga-Hospital Universitario Regional de Málaga, Málaga, Spain. [Gaetani,S] Department of Physiology and Pharmacology “V. Erspamer”, Sapienza University of Rome, Rome, Italy.
Keywords: Brain;Cannabinoid receptors;Endocannabinoid system;Food addiction;Obesity;Reward system;Encéfalo;Receptores de cannabinoides;Obesidad;Adicción a la comida;Endocannabinoides
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Endocannabinoids
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Psychophysiology::Appetite
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Nutrition Processes::Eating
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Terpenes::Cannabinoids
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Reinforcement (Psychology)::Reward
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Mood Disorders
Medical Subject Headings::Chemicals and Drugs::Pharmaceutical Preparations
Issue Date: 29-Sep-2021
Publisher: MDPI
Citation: De Ceglia M, Decara J, Gaetani S, Rodríguez de Fonseca F. Obesity as a Condition Determined by Food Addiction: Should Brain Endocannabinoid System Alterations Be the Cause and Its Modulation the Solution? Pharmaceuticals 2021,14,1002.
Abstract: Obesity is a complex disorder, and the number of people affected is growing every day. In recent years, research has confirmed the hypothesis that food addiction is a determining factor in obesity. Food addiction is a behavioral disorder characterized by disruptions in the reward system in response to hedonic eating. The endocannabinoid system (ECS) plays an important role in the central and peripheral control of food intake and reward-related behaviors. Moreover, both obesity and food addiction have been linked to impairments in the ECS function in various brain regions integrating peripheral metabolic signals and modulating appetite. For these reasons, targeting the ECS could be a valid pharmacological therapy for these pathologies. However, targeting the cannabinoid receptors with inverse agonists failed when used in clinical contexts as a consequence of the induction of affective disorders. In this context, new classes of drugs acting either on CB1 and/or CB2 receptors or on synthetic and degradation enzymes of endogenous cannabinoids are being studied. However, further investigation is necessary to find safe and effective treatments that can exert anti-obesity effects, normalizing reward-related behaviors without causing important adverse mood effects.
metadata.dc.identifier.doi: 10.3390/ph14101002
ISSN: 1424-8247 (online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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