Please use this identifier to cite or link to this item:
Title: Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming
Authors: Sanchez-Castro, E. Eduardo
Pajuelo-Reyes, Cecilia
Tejedo, Rebeca
Soria-Juan, Bárbara
Tapia-Limonchi, Rafael
Andreu, Etelvina
Hitos, Ana B.
Martin, Franz
Cahuana, Gladys M.
Guerra-Duarte, Clara
Silva de Assis, Thamyres C.
Bedoya, Francisco J.
Soria, Bernat
Chávez-Olórtegui, Carlos
Tejedo, Juan R.
metadata.dc.contributor.authoraffiliation: [Sanchez-Castro,EE] Faculty of Biological Sciences, Universidad Nacional Mayor de San Marcos, Lima, Peru. [Pajuelo-Reyes,C; Tapia-Limonchi,R; Tejedo,JR] Institute of Tropical Diseases, Universidad Nacional Toribio Rodríguez de Mendoza de Amazonas, Chachapoyas, Peru. [Tejedo,R] Faculty of Medicine, Universidad Privada San Juan Bautista, Lima, Peru. [Soria-Juan,B; Martin,F; Cahuana,GM; Bedoya,FJ; Soria,B; Tejedo,JR] Department of Molecular Biology and Biochemical Engineering, Universidad Pablo de Olavide, Seville, Spain. [Soria-Juan,B] Department of Surgery, Fundación Jiménez Díaz, Unidad de Terapias Avanzadas, Universidad Autónoma de Madrid, Madrid, Spain. [Andreu,E; Soria,B] ISABIAL-Hospital General y Universitario de Alicante, Alicante, Spain. [Andreu,E] Departamento de Física Aplicadas, University Miguel Hernández, Alicante, Spain. [Hitos,AB; Martín,F; Cahuana,GM; Bedoya,FJ; Tejedo,JR] Department of Cell Regeneration and Advanced Therapies, Andalusian Center of Molecular Biology and Regenerative Medicine-CABIMER, University of Pablo de Olavide University of Sevilla-CSIC, Seville, Spain. [Hitos,AB; Martin,F; Bedoya,FJ; Soria,B; Tejedo,JR] Biomedical Research Network for Diabetes and Related Metabolic Diseases— CIBERDEM, Instituto de Salud Carlos III, Madrid, Spain. [Guerra-Duarte,C] Center of Research and Development, Fundacão Ezequiel Dias, Belo Horizonte, Brazil. [Silva de Assis,TC; Chávez-Olórtegui,C] Departament of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. [Soria,B] Institute of Bioengineering, University Miguel Hernandez de Elche, Alicante, Spain.
Keywords: Advanced therapy medicinal products;Mesenchymal stromal cells;Snakebite;Envenoming;Muscle regeneration;Células madre mesenquimatosas;Mordeduras de serpientes;Envenenamiento
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Inflammation Mediators
Medical Subject Headings::Anatomy::Musculoskeletal System::Muscles::Muscle, Skeletal
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Monokines::Tumor Necrosis Factor-alpha
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antitoxins::Antivenins
Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::Signal Transduction
Medical Subject Headings::Diseases::Chemically-Induced Disorders::Poisoning::Bites and Stings::Snake Bites
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Mesenchymal Stem Cell Transplantation
Issue Date: 3-Feb-2021
Publisher: Frontiers
Citation: Sanchez-Castro EE, Pajuelo-Reyes C, Tejedo R, Soria-Juan B, Tapia-Limonchi R, Andreu E, et al. Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming. Front Immunol. 2021 Feb 3;11:609961.
Abstract: Snakebite envenoming is a global neglected disease with an incidence of up to 2.7 million new cases every year. Although antivenoms are so-far the most effective treatment to reverse the acute systemic effects induced by snakebite envenoming, they have a limited therapeutic potential, being unable to completely neutralize the local venom effects. Local damage, such as dermonecrosis and myonecrosis, can lead to permanent sequelae with physical, social, and psychological implications. The strong inflammatory process induced by snake venoms is associated with poor tissue regeneration, in particular the lack of or reduced skeletal muscle regeneration. Mesenchymal stromal cells (MSCs)-based therapies have shown both anti-inflammatory and pro-regenerative properties. We postulate that using allogeneic MSCs or their cell-free products can induce skeletal muscle regeneration in snakebite victims, improving all the three steps of the skeletal muscle regeneration process, mainly by anti-inflammatory activity, paracrine effects, neovascularization induction, and inhibition of tissue damage, instrumental for microenvironment remodeling and regeneration. Since snakebite envenoming occurs mainly in areas with poor healthcare, we enlist the principles and potential of MSCs-based therapies and discuss regulatory issues, good manufacturing practices, transportation, storage, and related-procedures that could allow the administration of these therapies, looking forward to a safe and cost-effective treatment for a so far unsolved and neglected health problem.
metadata.dc.identifier.doi: 10.3389/fimmu.2020.609961
ISSN: 1664-3224 (Online)
Appears in Collections:01- Artículos - CABIMER. Centro Andaluz de Biología Molecular

Files in This Item:
File Description SizeFormat 
SanchezCastro_MesenchymalStromal.pdfRevisión7,34 MBAdobe PDFView/Open

This item is protected by original copyright

This item is licensed under a Creative Commons License Creative Commons