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Title: Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring
Authors: Mustieles, Vicente
D'Cruz, Shereen Cynthia
Couderq, Stephan
Rodríguez-Carrillo, Andrea
Fini, Jean-Baptiste
Hofer, Tim
Steffensen, Inger-Lise
Dirven, Hubert
Barouki, Robert
Olea, Nicolás
Fernández, Mariana F.
David, Arthur
metadata.dc.contributor.authoraffiliation: [Mustieles,V; Rodríguez-Carrillo,A; Olea,N; Fernández,MF] University of Granada, Center for Biomedical Research (CIBM), Spain. [Mustieles,V; Olea,N; Fernández,MF] Instituto de Investigación Biosanitaria (ibs. GRANADA), Spain. [Mustieles,V; Olea,N; Fernández,MF] Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), Spain. [D'Cruz,SC; David,A] Univ Rennes, EHESP, Inserm, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085, Rennes, France. [Couderq,S; Fini,JB] Evolution des Régulations Endocriniennes, Département “Adaptation du Vivant", UMR 7221 MNHN/CNRS, Sorbonne Université, Paris, France. [Hofer,T; Steffensen,IL; Dirven,H] Section of Toxicology and Risk Assessment, Norwegian Institute of Public Health, P.O. Box 222 Skøyen, Oslo, Norway. [Barouki,R] University Paris Descartes, ComUE Sorbonne Paris Cité, Paris, France. Institut national de la santé et de la recherche médicale (INSERM, National Institute of Health & Medical Research) UMR S-1124, Paris, France.
Keywords: Bisphenol A;Bisphenol analogues;Human biomonitoring;Effect biomarker;Adverse outcome pathway;Fenoles;Monitoreo Biológico;Humanos;Biomarcadores;Rutas de resultados adversos
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenols
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Benzhydryl Compounds
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Stress, Physiological::Oxidative Stress
Medical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Plastics::Resins, Synthetic::Composite Resins::Bisphenol A-Glycidyl Methacrylate
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Endocrine Disruptors
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies
Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Transcription, Genetic
Issue Date: 28-Aug-2020
Publisher: Elsevier
Citation: Mustieles V, D'Cruz SC, Couderq S, Rodríguez-Carrillo A, Fini JB, Hofer T, et al. Bisphenol A and its analogues: A comprehensive review to identify and prioritize effect biomarkers for human biomonitoring. Environ Int. 2020 Nov;144:105811
Abstract: Human biomonitoring (HBM) studies have demonstrated widespread and daily exposure to bisphenol A (BPA). Moreover, BPA structural analogues (e.g. BPS, BPF, BPAF), used as BPA replacements, are being increasingly detected in human biological matrices. BPA and some of its analogues are classified as endocrine disruptors suspected of contributing to adverse health outcomes such as altered reproduction and neurodevelopment, obesity, and metabolic disorders among other developmental and chronic impairments. One of the aims of the H2020 European Human Biomonitoring Initiative (HBM4EU) is the implementation of effect biomarkers at large scales in future HBM studies in a systematic and standardized way, in order to complement exposure data with mechanistically-based biomarkers of early adverse effects. This review aimed to identify and prioritize existing biomarkers of effect for BPA, as well as to provide relevant mechanistic and adverse outcome pathway (AOP) information in order to cover knowledge gaps and better interpret effect biomarker data. A comprehensive literature search was performed in PubMed to identify all the epidemiologic studies published in the last 10 years addressing the potential relationship between bisphenols exposure and alterations in biological parameters. A total of 5716 references were screened, out of which, 119 full-text articles were analyzed and tabulated in detail. This work provides first an overview of all epigenetics, gene transcription, oxidative stress, reproductive, glucocorticoid and thyroid hormones, metabolic and allergy/immune biomarkers previously studied. Then, promising effect biomarkers related to altered neurodevelopmental and reproductive outcomes including brain-derived neurotrophic factor (BDNF), kisspeptin (KiSS), and gene expression of nuclear receptors are prioritized, providing mechanistic insights based on in vitro, animal studies and AOP information. Finally, the potential of omics technologies for biomarker discovery and its implications for risk assessment are discussed. To the best of our knowledge, this is the first effort to comprehensively identify bisphenol-related biomarkers of effect for HBM purposes.
metadata.dc.identifier.doi: 10.1016/j.envint.2020.105811
ISSN: 0160-4120 (Print)
1873-6750 (Online)
Appears in Collections:01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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