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Title: Protective Role of Nrf2 in Renal Disease
Authors: Guerrero-Hue, Melania
Rayego-Mateos, Sandra
Vázquez-Carballo, Cristina
Palomino-Antolín, Alejandra
García-Caballero, Cristina
Opazo-Rios, Lucas
Morgado-Pascual, José Luis
Herencia, Carmen
Mas, Sebastián
Ortiz, Alberto
Rubio-Navarro, Alfonso
Egea, Javier
Villalba, José Manuel
Egido, Jesús
Moreno, Juan Antonio
metadata.dc.contributor.authoraffiliation: [Guerrero-Hue,M; Rayego-Mateos,S; García-Caballero,C; Morgado-Pascual,JL; Moreno,JA] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. [Vázquez-Carballo,C; Opazo-Rios,L; Herencia,C; Mas,S; Ortiz,A; Egido,J] Instituto de Investigación Sanitaria (IIS)-Fundación Jiménez Díaz, Autónoma University, Madrid, Spain. [Palomino-Antolín,A; Egea,J] Research Unit, Hospital Universitario Santa Cristina, IIS-Hospital Universitario de la Princesa, Madrid, Spain. [Palomino-Antolín,A; Egea,J] Departament of Pharmacology and Therapeutics, Medicine Faculty, Instituto Teófilo Hernando, Autónoma University, Madrid, Spain. [Opazo-Rios,L; Mas,S; Egido,J] Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain. [Ortiz,A] Red Nacional Investigaciones Nefrológicas (REDINREN), Madrid, Spain. [Rubio-Navarro,A] Weill Center for Metabolic Health and Division of Cardiology, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. [Villalba,JM; Moreno,JA] Department of Cell Biology, Physiology, and Immunology, Agrifood Campus of International Excellence (ceiA3), University of Cordoba, Cordoba, Spain. [Moreno,JA] Hospital Universitario Reina Sofia, Cordoba, Spain. [Moreno,JA] Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Madrid, Spain.
Keywords: Nrf2;Renal disease;Acute kidney injury;Oxidative stress;Inflammatory response;Factor 1 relacionado con NF-E2;Enfermedades renales;Lesión renal aguda;Estrés oxidativo;Inflamación
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Basic-Leucine Zipper Transcription Factors::NF-E2-Related Factor 2
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Mortality::Cause of Death
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress
Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Renal Insufficiency, Chronic
Medical Subject Headings::Anatomy::Urogenital System::Urinary Tract::Kidney
Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney Injury
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Issue Date: 31-Dec-2020
Publisher: MDPI
Citation: Guerrero-Hue M, Rayego-Mateos S, Vázquez-Carballo C, Palomino-Antolín A, García-Caballero C, Opazo-Rios L, et al. Protective Role of Nrf2 in Renal Disease. Antioxidants. 2020 Dec 31;10(1):39.
Abstract: Chronic kidney disease (CKD) is one of the fastest-growing causes of death and is predicted to become by 2040 the fifth global cause of death. CKD is characterized by increased oxidative stress and chronic inflammation. However, therapies to slow or prevent CKD progression remain an unmet need. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that plays a key role in protection against oxidative stress and regulation of the inflammatory response. Consequently, the use of compounds targeting Nrf2 has generated growing interest for nephrologists. Pre-clinical and clinical studies have demonstrated that Nrf2-inducing strategies prevent CKD progression and protect from acute kidney injury (AKI). In this article, we review current knowledge on the protective mechanisms mediated by Nrf2 against kidney injury, novel therapeutic strategies to induce Nrf2 activation, and the status of ongoing clinical trials targeting Nrf2 in renal diseases.
metadata.dc.identifier.doi: 10.3390/antiox10010039
ISSN: 2076-3921 (Online)
Appears in Collections:01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba

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