Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3640
Title: Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
Authors: Nieto-Quero, Andrea
Chaves-Peña, Patricia
Santín, Luis J.
Pérez-Martín, Margarita
Pedraza, Carmen
metadata.dc.contributor.authoraffiliation: [Nieto-Quero,A; Chaves-Peña,P; Santín,LJ; Pedraza,C] Departamento de Psicobiología y Metodología en las CC, Universidad de Málaga, Málaga, Spain. [Chaves-Peña,P; Pérez-Martín,M] Departamento de Biología Celular, Genética y Fisiología, Universidad de Málaga, Málaga, Spain. [Nieto-Quero,A; Santín,LJ; Pérez-Martín,M; Pedraza,C] Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
Keywords: Psychosocial stress;Neurogenesis;Microglia;Neuroinflammation;Depression;Animal models;Systematic review;Neurogénesis;Modelos animales;Microglía;Neurogénesis;Depresión;Modelos animales;Revisión sistemática
metadata.dc.subject.mesh: Medical Subject Headings::Anatomy::Nervous System::Neuroglia::Microglia
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Health
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation::Neurogenesis
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Stress, Psychological
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Mood Disorders
Medical Subject Headings::Organisms::Eukaryota::Animals
Issue Date: 18-Jun-2021
Publisher: Elsevier
Citation: Nieto-Quero A, Chaves-Peña P, Santín LJ, Pérez-Martín M, Pedraza C. Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models. Neurobiol Stress. 2021 Jun 18;15:100356
Abstract: Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The hippocampus is a target structure of the adverse effects of stress, and hippocampal neurogenesis plays a crucial role. However, we do not know the mechanisms by which stress impacts neurogenesis. Recent studies indicate that changes in neuroinflammation, primarily via microglial cells, may play an essential role in this process. However, the relationship between stress, microglial changes, and alterations in neurogenesis and their involvement in the development of depression is poorly characterized. For this reason, this systematic review aims to synthesise and evaluate current studies that have investigated the relationship between these variables. Taken together, the revised data, although not entirely conclusive, seem to suggest that microglial changes induced by psychological stress regulate neurogenesis and in turn may be responsible for the development of depressive-like behaviours, but other factors that influence these stressful experiences should not be dismissed.
URI: http://hdl.handle.net/10668/3640
metadata.dc.relation.publisherversion: https://www.sciencedirect.com/science/article/pii/S2352289521000643?via%3Dihub
metadata.dc.identifier.doi: 10.1016/j.ynstr.2021.100356
ISSN: 2352-2895 (Online)
Appears in Collections:01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

Files in This Item:
File Description SizeFormat 
NietoQuero_DoChanges.pdfArtículo original3,21 MBAdobe PDFView/Open


This item is protected by original copyright



This item is licensed under a Creative Commons License Creative Commons