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Title: Primary and Acquired Resistance to Immunotherapy in Lung Cancer: Unveiling the Mechanisms Underlying of Immune Checkpoint Blockade Therapy
Authors: Boyero, Laura
Sánchez-Gastaldo, Amparo
Alonso, Miriam
Noguera-Uclés, José Francisco
Molina-Pinelo, Sonia
Bernabé-Caro, Reyes
metadata.dc.contributor.authoraffiliation: [Boyero,L; Noguera-Uclés,JF; Molina-Pinelo,S; Bernabé-Caro,R] Institute of Biomedicine of Seville (IBiS) (HUVR, CSIC, Universidad de Sevilla), Seville, Spain. [Sánchez-Gastaldo,A; Alonso,M; Molina-Pinelo,S; Bernabé-Caro,R] Medical Oncology Department, Hospital Universitario Virgen del Rocio, Seville, Spain. [Molina-Pinelo,S] Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
Keywords: Lung cancer;Immunotherapy;Resistance mechanisms;PD-1/PD-L1;Immune checkpoint inhibitors;Monoclonal antibodies;NSCLC;SCLC;Neoplasias pulmonares;Inmunoterapia;Receptor de muerte celular programada 1;Antígeno B7-H1;Inhibidores de puntos de control inmunológico;Anticuerpos monoclonales;Carcinoma de pulmón de células no pequeñas;Carcinoma pulmonar de células pequeñas
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anthropology, Education, Sociology and Social Phenomena::Social Sciences::Quality of Life
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cellular Microenvironment::Tumor Microenvironment
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Thoracic Neoplasms::Respiratory Tract Neoplasms::Lung Neoplasms
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Signal Transduction
Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiota
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Recurrence
Issue Date: 11-Dec-2020
Publisher: MDPI
Citation: Boyero L, Sánchez-Gastaldo A, Alonso M, Noguera-Uclés JF, Molina-Pinelo S, Bernabé-Caro R. Primary and Acquired Resistance to Immunotherapy in Lung Cancer: Unveiling the Mechanisms Underlying of Immune Checkpoint Blockade Therapy. Cancers. 2020 Dec 11;12(12):3729
Abstract: After several decades without maintained responses or long-term survival of patients with lung cancer, novel therapies have emerged as a hopeful milestone in this research field. The appearance of immunotherapy, especially immune checkpoint inhibitors, has improved both the overall survival and quality of life of patients, many of whom are diagnosed late when classical treatments are ineffective. Despite these unprecedented results, a high percentage of patients do not respond initially to treatment or relapse after a period of response. This is due to resistance mechanisms, which require understanding in order to prevent them and develop strategies to overcome them and increase the number of patients who can benefit from immunotherapy. This review highlights the current knowledge of the mechanisms and their involvement in resistance to immunotherapy in lung cancer, such as aberrations in tumor neoantigen burden, effector T-cell infiltration in the tumor microenvironment (TME), epigenetic modulation, the transcriptional signature, signaling pathways, T-cell exhaustion, and the microbiome. Further research dissecting intratumor and host heterogeneity is necessary to provide answers regarding the immunotherapy response and develop more effective treatments for lung cancer.
metadata.dc.identifier.doi: 10.3390/cancers12123729
ISSN: 2072-6694 (Online)
Appears in Collections:01- Artículos - Hospital Virgen del Rocío
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla

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