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Title: The Gut Barrier, Intestinal Microbiota, and Liver Disease: Molecular Mechanisms and Strategies to Manage
Authors: Plaza-Díaz, Julio
Solís-Urra, Patricio
Rodríguez-Rodríguez, Fernando
Olivares-Arancibia, Jorge
Navarro-Oliveros, Miguel
Abadía-Molina, Francisco
Álvarez-Mercado, Ana I.
metadata.dc.contributor.authoraffiliation: [Plaza-Díaz,J] Children’s Hospital of Eastern Ontario Research Institute, Ottawa, Canada. [Plaza-Díaz,J; Álvarez-Mercado,AI] Department of Biochemistry and Molecular Biology II, School of Pharmacy, University of Granada, Granada, Spain. [Plaza-Díaz,J; Álvarez-Mercado,AI] Instituto de Investigación Biosanitaria IBS.GRANADA, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Solís-Urra,P] Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar, Chile. [Rodríguez-Rodríguez,F; Olivares-Arancibia,J] IRyS Research Group, School of Physical Education, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile. [Olivares-Arancibia,J] Escuela de Pedagogía en Educación Física, Facultad de Educación, Universidad de las Américas, Santiago, Chile. [Navarro-Oliveros,M] BioCritic. Group for Biomedical Research in Critical Care Medicine, Valladolid, Spain. [Abadía-Molina,F; Álvarez-Mercado,AI] Institute of Nutrition and Food Technology “José Mataix”, Center of Biomedical Research, University of Granada, Armilla, Granada, Spain. [Abadía-Molina,F] Department of Cell Biology, School of Sciences, University of Granada, Granada, Spain.
Keywords: Liver disease;Intestinal barrier;Intestinal permeability;Microbiota;Hepatopatías;Permeabilidad;Microbioma gastrointestinal;Hígado
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Organisms::Bacteria
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Dysbiosis
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::Intestines::Intestinal Mucosa
Medical Subject Headings::Anatomy::Digestive System::Liver
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Liver Diseases, Alcoholic
Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiota
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver
Issue Date: 7-Nov-2020
Publisher: MDPI
Citation: Plaza-Díaz J, Solís-Urra P, Rodríguez-Rodríguez F, Olivares-Arancibia J, Navarro-Oliveros M, Abadía-Molina F, et al. The Gut Barrier, Intestinal Microbiota, and Liver Disease: Molecular Mechanisms and Strategies to Manage. Int J Mol Sci. 2020 Nov 7;21(21):8351
Abstract: Liver disease encompasses pathologies as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, alcohol liver disease, hepatocellular carcinoma, viral hepatitis, and autoimmune hepatitis. Nowadays, underlying mechanisms associating gut permeability and liver disease development are not well understood, although evidence points to the involvement of intestinal microbiota and their metabolites. Animal studies have shown alterations in Toll-like receptor signaling related to the leaky gut syndrome by the action of bacterial lipopolysaccharide. In humans, modifications of the intestinal microbiota in intestinal permeability have also been related to liver disease. Some of these changes were observed in bacterial species belonging Roseburia, Streptococcus, and Rothia. Currently, numerous strategies to treat liver disease are being assessed. This review summarizes and discusses studies addressed to determine mechanisms associated with the microbiota able to alter the intestinal barrier complementing the progress and advancement of liver disease, as well as the main strategies under development to manage these pathologies. We highlight those approaches that have shown improvement in intestinal microbiota and barrier function, namely lifestyle changes (diet and physical activity) and probiotics intervention. Nevertheless, knowledge about how such modifications are beneficial is still limited and specific mechanisms involved are not clear. Thus, further in-vitro, animal, and human studies are needed.
metadata.dc.identifier.doi: 10.3390/ijms21218351
ISSN: 1422-0067 (Online)
Appears in Collections:01- Artículos - Complejo Hospitalario Universitario de Granada
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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