Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3701
Title: Microbiota insights in clostridium difficile infection and inflammatory bowel disease
Authors: Rodríguez, C.
Romero, E.
Garrido-Sanchez, L.
Alcaín-Martínez, G.
Andrade, R.J.
Taminiau, B.
Daube, G.
García-Fuentes, E.
metadata.dc.contributor.authoraffiliation: [Rodríguez,C; Romero,E; Garrido-Sanchez,L; Alcaín-Martínez,G; Andrade,RJ; García-Fuentes,E] Instituto de Investigación Biomédica de Málaga-IBIMA, Málaga, Spain. [Rodríguez,C; Alcaín-Martínez,G; Andrade,RJ; García-Fuentes,E] Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Garrido-Sanchez,L] Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Andrade,RJ] Department of Medicine and Dermatology, Universidad de Málaga, Málaga, Spain. [Andrade,RJ] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Málaga, Spain. [Taminiau,B; Daube,G] Fundamental and Applied Research for Animals & Health (FARAH), Department of Food Microbiology, Faculty of Veterinary Medicine, University of Liège, Liège, Belgium.
Keywords: C. difficile;Inflammatory bowel disease;Microbial communities;Microbial metabolites;Interactions;Clostridioides difficile;Enfermedades inflamatorias del intestino;Microbiota
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Dysbiosis
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Gastroenteritis::Enterocolitis
Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiota
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Inflammatory Bowel Diseases
Medical Subject Headings::Anatomy::Digestive System::Gastrointestinal Tract::Intestines
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Colonic Diseases::Colitis::Colitis, Ulcerative
Medical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Inflammatory Bowel Diseases
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Metabolic Networks and Pathways
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Growth::Cell Growth Processes::Cell Proliferation
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Signs and Symptoms, Digestive::Diarrhea
Issue Date: 4-Mar-2020
Publisher: Taylor & Francis
Citation: Rodríguez C, Romero E, Garrido-Sanchez L, Alcaín-Martínez G, Andrade RJ, Taminiau B, et al. Microbiota insights in clostridium difficile infection and inflammatory bowel disease. Gut Microbes. 2020 nov 9;12(1):1725220
Abstract: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation that includes Crohn´s disease (CD) and ulcerative colitis (UC). Although the etiology is still unknown, some specific factors have been directly related to IBD, including genetic factors, abnormal intestinal immunity, and/or gut microbiota modifications. Recent findings highlight the primary role of the gut microbiota closely associated with a persistent inappropriate inflammatory response. This gut environment of dysbiosis in a susceptible IBD host can increasingly worsen and lead to colonization and infection with some opportunistic pathogens, especially Clostridium difficile. C. difficile is an intestinal pathogen considered the main cause of antibiotic-associated diarrhea and colitis and an important complication of IBD, which can trigger or worsen an IBD flare. Recent findings have highlighted the loss of bacterial cooperation in the gut ecosystem, as well as the pronounced intestinal dysbiosis, in patients suffering from IBD and concomitant C. difficile infection (CDI). The results of intestinal microbiota studies are still limited and often difficult to compare because of the variety of disease conditions. However, these data provide important clues regarding the main modifications and interrelations in the complicated gut ecosystem to better understand both diseases and to take advantage of the development of new therapeutic strategies. In this review, we analyze in depth the gut microbiota changes associated with both forms of IBD and CDI and their similarity with the dysbiosis that occurs in CDI. We also discuss the metabolic pathways that favor the proliferation or decrease in several important taxa directly related to the disease.
URI: http://hdl.handle.net/10668/3701
metadata.dc.relation.publisherversion: https://www.tandfonline.com/doi/full/10.1080/19490976.2020.1725220
metadata.dc.identifier.doi: 10.1080/19490976.2020.1725220
ISSN: 1949-0976 (Print)
1949-0984 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

Files in This Item:
File Description SizeFormat 
Rodriguez_MicrobiotaInsights.pdfRevisión2,5 MBAdobe PDFView/Open


This item is protected by original copyright



This item is licensed under a Creative Commons License Creative Commons