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Title: Peripheral inflammation increases the damage in animal models of nigrostriatal dopaminergic neurodegeneration: possible implication in Parkinson's disease incidence.
Authors: Machado, A.
Herrera, A.J.
Venero, J.L.
Santiago, M.
De Pablos, R.M.
Villarán, R.F.
Espinosa-Oliva, A.M.
Argüelles, S.
Sarmiento, M.
Delgado-Cortés, M.J.
Mauriño, R.
Cano, J.
metadata.dc.contributor.authoraffiliation: [Machado,A; Herrera,AJ; Venero,JL; Santiago,M; De Pablos,RM; Villarán,RF; Espinosa-Oliva,AM; Argüelles,S; Sarmiento,M; Delgado-Cortés,MJ; Mauriño,R; Cano,J] Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain. [Machado,A; Herrera,AJ; Venero,JL; Santiago,M; De Pablos,RM; Villarán,RF; Espinosa-Oliva,AM; Argüelles,S; Sarmiento,M; Delgado-Cortés,MJ; Mauriño,R; Cano,J] Instituto de Biomedicina de Sevilla (IBiS)y Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, Spain.
Keywords: Enfermedad de Parkinson;Sustancia negra
metadata.dc.subject.mesh: Medical Subject Headings::Anatomy::Nervous System::Peripheral Nervous System
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Catecholamines::Dopamine
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Brain Stem::Mesencephalon::Tegmentum Mesencephali::Substantia Nigra
Medical Subject Headings::Publication Characteristics::Publication Formats::Journal Article::Review
Issue Date: 21-Feb-2011
Publisher: Hindawi Publishing Corporation
Citation: Machado A, Herrera AJ, Venero JL, Santiago M, De Pablos RM, Villarán RF. Peripheral Inflammation Increases the Damage in Animal Models of Nigrostriatal Dopaminergic Neurodegeneration: Possible Implication in Parkinson's Disease Incidence.Parkinsons Dis.2011;(2011): Article ID393769
Abstract: Inflammatory processes described in Parkinson’s disease (PD) and its animal models appear to be important in the progression of the pathogenesis, or even a triggering factor. Here we review that peripheral inflammation enhances the degeneration of the nigrostriatal dopaminergic system induced by different insults; different peripheral inflammations have been used, such as IL-1β and the ulcerative colitis model, as well as insults to the dopaminergic system such as 6-hydroxydopamine or lipopolysaccharide. In all cases, an increased loss of dopaminergic neurons was described; inflammation in the substantia nigra increased, displaying a great activation of microglia along with an increase in the production of cytokines such as IL-1β and TNF-α. Increased permeability or disruption of the BBB, with overexpression of the ICAM-1 adhesion molecule and infiltration of circulating monocytes into the substantia nigra, is also involved, since the depletion of circulating monocytes prevents the effects of peripheral inflammation. Data are reviewed in relation to epidemiological studies of PD.
Description: Review Article
metadata.dc.identifier.doi: 10.4061/2011/393769
ISSN: 2042-0080
Appears in Collections:01- Artículos - Hospital Virgen del Rocío
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla

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