Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/375
Title: Role of Leptin in the Activation of Immune Cells
Authors: Fernández-Riejos, Patricia
Najib, Souad
Santos-Alvarez, Jose
Martín-Romero, Consuelo
Pérez-Pérez, Antonio
González-Yanes, Carmen
Sánchez-Margalet, Víctor
metadata.dc.contributor.authoraffiliation: [Fernández,P; Najib,S; Santos,J; Martín,C; Pérez,A; González,C; Sánchez,V] Department of Clinical Biochemistry, Virgen Macarena University Hospital, University of Seville, Seville, Spain
Keywords: atherosclerosis;Leptin;tejido adiposo;adipocinas;ateroesclerosis;leptina
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Leptin
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines
Medical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue
Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::Atherosclerosis
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Immunity, Innate
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Cellular::Lymphocyte Activation
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Issue Date: 23-Mar-2010
Publisher: Hindawi Publishing Corporation
Citation: Fernández-Riejos P, Najib S, Santos-Alvarez J, Martín-Romero C, Pérez-Pérez A, González-Yanes C, et al. Role of Leptin in the Activation of Immune Cells. Mediators Inflamm. 2010 (2010): Article ID 568343
Abstract: Adipose tissue is an active endocrine organ that secretes various humoral factors (adipokines), and its shift to production of proinflammatory cytokines in obesity likely contributes to the low-level systemic inflammation that may be present in metabolic syndrome-associated chronic pathologies such as atherosclerosis. Leptin is one of the most important hormones secreted by adipocytes, with a variety of physiological roles related to the control of metabolism and energy homeostasis. One of these functions is the connection between nutritional status and immune competence. The adipocyte-derived hormone leptin has been shown to regulate the immune response, innate and adaptive response, both in normal and pathological conditions. The role of leptin in regulating immune response has been assessed in vitro as well as in clinical studies. It has been shown that conditions of reduced leptin production are associated with increased infection susceptibility. Conversely, immune-mediated disorders such as autoimmune diseases are associated with increased secretion of leptin and production of proinflammatory pathogenic cytokines. Thus, leptin is a mediator of the inflammatory response
Description: Review Article
URI: http://hdl.handle.net/10668/375
metadata.dc.relation.publisherversion: http://www.hindawi.com/journals/mi/2010/568343/
metadata.dc.identifier.doi: 10.1155/2010/568343
ISSN: 0962-9351 (Print)
1466-1861 (Online)
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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