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Title: The Immune System through the Lens of Alcohol Intake and Gut Microbiota
Authors: Calleja-Conde, Javier
Echeverry-Alzate, Victor
Bühler, Kora-Mareen
Durán-González, Pedro
Morales-García, Jose Ángel
Segovia-Rodríguez, Lucía
Rodríguez de Fonseca, Fernando
Giné, Elena
López-Moreno, Jose Antonio
metadata.dc.contributor.authoraffiliation: [Calleja-Conde,J; Echeverry-Alzate,V; Bühler,KM; Durán-González,P; Segovia-Rodríguez,L; López-Moreno,JA] Departamento de Psicobiología y Metodología en Ciencias del Comportamiento, Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain. [Echeverry-Alzate,V; Rodríguez de Fonseca,F] Unidad Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Malaga University, Málaga, Spain. [Echeverry-Alzate,V] Universidad Nebrija, Campus Madrid-Princesa, 28015 Madrid, Spain. [Morales-García,JÁ] Instituto de Investigaciones Biomédicas (CSIC-UAM) “Alberto Sols” (CSIC-UAM), Madrid, Spain. [Morales-García,JÁ; Giné,E] Departamento de Biología Celular, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain. [Morales-García,JÁ] Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
Keywords: Alcohol;Gut;Microbiota;Brain;Liver;Immune system;Dysbiosis;Microbioma gastrointestinal;Encéfalo;HígadoSistema inmunológico;Sistema inmunológico;Disbiosis
metadata.dc.subject.mesh: Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinking
Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Dysbiosis
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Hemic and Immune Systems::Immune System
Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Permeability
Medical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Immunity, Mucosal
Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiota
Issue Date: 13-Jul-2021
Publisher: MDPI
Citation: Calleja-Conde J, Echeverry-Alzate V, Bühler KM, Durán-González P, Morales-García JÁ, Segovia-Rodríguez L, et al. The Immune System through the Lens of Alcohol Intake and Gut Microbiota. Int J Mol Sci. 2021 Jul 13;22(14):7485
Abstract: The human gut is the largest organ with immune function in our body, responsible for regulating the homeostasis of the intestinal barrier. A diverse, complex and dynamic population of microorganisms, called microbiota, which exert a significant impact on the host during homeostasis and disease, supports this role. In fact, intestinal bacteria maintain immune and metabolic homeostasis, protecting our organism against pathogens. The development of numerous inflammatory disorders and infections has been linked to altered gut bacterial composition or dysbiosis. Multiple factors contribute to the establishment of the human gut microbiota. For instance, diet is considered as one of the many drivers in shaping the gut microbiota across the lifetime. By contrast, alcohol is one of the many factors that disrupt the proper functioning of the gut, leading to a disruption of the intestinal barrier integrity that increases the permeability of the mucosa, with the final result of a disrupted mucosal immunity. This damage to the permeability of the intestinal membrane allows bacteria and their components to enter the blood tissue, reaching other organs such as the liver or the brain. Although chronic heavy drinking has harmful effects on the immune system cells at the systemic level, this review focuses on the effect produced on gut, brain and liver, because of their significance in the link between alcohol consumption, gut microbiota and the immune system.
metadata.dc.identifier.doi: 10.3390/ijms22147485
ISSN: 1422-0067 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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