Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/375
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dc.contributor.authorFernández-Riejos, Patricia-
dc.contributor.authorNajib, Souad-
dc.contributor.authorSantos-Alvarez, Jose-
dc.contributor.authorMartín-Romero, Consuelo-
dc.contributor.authorPérez-Pérez, Antonio-
dc.contributor.authorGonzález-Yanes, Carmen-
dc.contributor.authorSánchez-Margalet, Víctor-
dc.date.accessioned2012-03-28T11:33:19Z-
dc.date.available2012-03-28T11:33:19Z-
dc.date.issued2010-03-23-
dc.identifier.citationFernández-Riejos P, Najib S, Santos-Alvarez J, Martín-Romero C, Pérez-Pérez A, González-Yanes C, et al. Role of Leptin in the Activation of Immune Cells. Mediators Inflamm. 2010 (2010): Article ID 568343es
dc.identifier.issn0962-9351 (Print)-
dc.identifier.issn1466-1861 (Online)-
dc.identifier.otherPMC2846344-
dc.identifier.urihttp://hdl.handle.net/10668/375-
dc.descriptionReview Articlees
dc.description.abstractAdipose tissue is an active endocrine organ that secretes various humoral factors (adipokines), and its shift to production of proinflammatory cytokines in obesity likely contributes to the low-level systemic inflammation that may be present in metabolic syndrome-associated chronic pathologies such as atherosclerosis. Leptin is one of the most important hormones secreted by adipocytes, with a variety of physiological roles related to the control of metabolism and energy homeostasis. One of these functions is the connection between nutritional status and immune competence. The adipocyte-derived hormone leptin has been shown to regulate the immune response, innate and adaptive response, both in normal and pathological conditions. The role of leptin in regulating immune response has been assessed in vitro as well as in clinical studies. It has been shown that conditions of reduced leptin production are associated with increased infection susceptibility. Conversely, immune-mediated disorders such as autoimmune diseases are associated with increased secretion of leptin and production of proinflammatory pathogenic cytokines. Thus, leptin is a mediator of the inflammatory responsees
dc.language.isoenes
dc.publisherHindawi Publishing Corporationes
dc.relation.ispartofMediators of Inflammationes
dc.subjectatherosclerosises
dc.subjectLeptines
dc.subjecttejido adiposoes
dc.subjectadipocinases
dc.subjectateroesclerosises
dc.subjectleptinaes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Leptines
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunityes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokineses
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissuees
dc.subject.meshMedical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis::Atherosclerosises
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Immunity, Innatees
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammationes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immunity::Adaptive Immunity::Immunity, Cellular::Lymphocyte Activationes
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesityes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.titleRole of Leptin in the Activation of Immune Cellses
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1155/2010/568343-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://www.hindawi.com/journals/mi/2010/568343/es
dc.contributor.authoraffiliation[Fernández,P; Najib,S; Santos,J; Martín,C; Pérez,A; González,C; Sánchez,V] Department of Clinical Biochemistry, Virgen Macarena University Hospital, University of Seville, Seville, Spaines
dc.type.subtypeRevisión-
Appears in Collections:01- Artículos - Hospital Virgen Macarena

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