Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/380
Título : Ki-67 MIB1 labelling index and the prognosis of primary TaT1 urothelial cell carcinoma of the bladder.
Autor : Quintero, A
Alvarez-Kindelan, J
Luque, RJ
Gonzalez-Campora, R
Requena, MJ
Montironi, R
Lopez-Beltran, A
Filiación: [Quintero,A] Biomedical Research Unit, Reina Sofia University Hospital and Cordoba University Medical School, Cordoba, Spain.[Alvarez-Kindelan,J; Requena,MJ] Urology Service, Reina Sofia University Hospital and Cordoba University Medical School. [Luque,RJ] Department of Pathology, University Hospitals, Jaen, Spain. [Gonzalez-Campora,R] Department of Pathology, University Hospitals, Seville, Spain. [Montironi,R] Institute of Pathological Anatomy and Histopathology, Polytechnic University of the Marche Region Ancona,Italy. [Lopez-Beltran,A] Department of Pathology, Reina Sofia University Hospital and Cordoba University Medical School, Cordoba,Spain
Palabras clave : carcinoma
cell
bladder
pronóstico
carcinoma
celulas
vejiga
MeSH: Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Carcinoma, Papillary
Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Carcinoma, Transitional Cell
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Progression
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Molecular Probe Techniques::Immunoassay::Immunoenzyme Techniques
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Nuclear::Ki-67 Antigen
Medical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Invasiveness
Medical Subject Headings::Diseases::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, Local
Medical Subject Headings::Diseases::Virus Diseases::Tumor Virus Infections::Papillomavirus Infections
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers::Tumor Markers, Biological
Medical Subject Headings::Diseases::Male Urogenital Diseases::Urogenital Neoplasms::Urologic Neoplasms::Urinary Bladder Neoplasms
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Fecha de publicación : Jan-2006
Editorial : BMJ Publishing Group
Cita Bibliográfica: Quintero A, Alvarez-Kindelan J, Luque RJ, Gonzalez-Campora R, Requena MJ, Montironi R, et al. Ki-67 MIB1 labelling index and the prognosis of primary TaT1 urothelial cell carcinoma of the bladder. J Clin Pathol. 2006 Jan;59(1):83-8.
Abstract: Aims: To evaluate whether ki-67 labelling index (LI) has independent prognostic value for survival of patients with bladder urothelial tumours graded according to the 2004 World Health Organisation classification. Methods: Ki-67 LI was evaluated in 164 cases using the grid counting method. Non-invasive (stage Ta) tumours were: papilloma (n = 5), papillary urothelial neoplasia of low malignant potential (PUNLMP; n = 26), and low (LG; n = 34) or high grade (HG; n = 15) papillary urothelial carcinoma. Early invasive (stage T1) tumours were: LG (n = 58) and HG (n = 26) carcinoma. Statistical analysis included Fisher and x2 tests, and mean comparisons by ANOVA and t test. Univariate and multivariate survival analyses were performed according to the Kaplan–Meier method with log rank test and Cox’s proportional hazard method. Results: Mean ki-67 LI increased from papilloma to PUNLMP, LG, and HG in stage Ta (p,0.0001) and from LG to HG in stage T1 (p = 0.013) tumours. High tumour proliferation (.13%) was related to greater tumour size (p = 0.036), recurrence (p = 0.036), progression (p = 0.035), survival (p = 0.054), and high p53 accumulation (p = 0.015). Ki-67 LI and tumour size were independent predictors of disease free survival (DFS), but only ki-67 LI was related to progression free survival (PFS). Cancer specific overall survival (OS) was related to ki-67 LI, tumour size, and p27kip1 downregulation. Ki-67 LI was the main independent predictor of DFS (p = 0.0005), PFS (p = 0.0162), and cancer specific OS (p = 00195). Conclusion: Tumour proliferation measured by Ki-67 LI is related to tumour recurrence, stage progression, and is an independent predictor of DFS, PFS, and cancer specific OS in TaT1 bladder urothelial cell carcinoma.
Descripción : Artículo original
URI: http://hdl.handle.net/10668/380
Versión del editor : http://jcp.bmj.com/content/59/1/83.abstract
DOI: 10.1136/jcp.2004.022939
ISSN : 0021-9746
Appears in Collections:01- Artículos - Complejo Hospitalario de Jaén
01- Artículos - Hospital Reina Sofía
01- Artículos - Hospital Virgen Macarena

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