Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3890
Title: Early overnutrition sensitizes the growth hormone axis to the impact of diet-induced obesity via sex-divergent mechanisms
Authors: Sanchez-Garrido, M.A.
Ruiz-Pino, F.
Pozo-Salas, A.I.
Castellano, J.M.
Vazquez, M.J.
Luque, R.M.
Tena-Sempere, M.
metadata.dc.contributor.authoraffiliation: [Sanchez-Garrido,MA; Ruiz-Pino,F; Pozo-Salas,AI; Castellano,JM; Vazquez,MJ; Luque,RM; Tena-Sempere,M] Maimónides Institute of Biomedical Research of Córdoba (IMIBIC), Córdoba, Spain. [Sanchez-Garrido,MA; Ruiz-Pino,F; Pozo-Salas,AI; Castellano,JM; Vazquez,MJ; Luque,RM; Tena-Sempere,M] Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, University of Córdoba, Córdoba, Spain. [Castellano,JM; Luque,RM; Tena-Sempere,M] Reina Sofa University Hospital, Córdoba, Spain. [Castellano,JM; Luque,RM; Tena-Sempere,M] CIBER Fisiopatología de La Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Córdoba, Spain. [Tena-Sempere,M] Institute of Biomedicine, University of Turku, Turku, Finland.
Keywords: Overnutrition;Obesity;Growth hormone;Sex characteristics;Hipernutrición;Obesidad;Hormona del crecimiento;Características sexuales;Metabolismo
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones::Pituitary Hormones, Anterior::Growth Hormone
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Somatomedins::Insulin-Like Growth Factor I
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Models, Biological
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Organ Specificity
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition
Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messenger
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Wistar
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Peptide::Receptors, Neuropeptide::Receptors, Somatotropin
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, High-Fat
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Sex Characteristics
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism
Issue Date: 17-Aug-2020
Publisher: Springer Nature
Citation: Sanchez-Garrido MA, Ruiz-Pino F, Pozo-Salas AI, Castellano JM, Vazquez MJ, Luque RM, et al. Early overnutrition sensitizes the growth hormone axis to the impact of diet-induced obesity via sex-divergent mechanisms. Sci Rep. 2020 Aug 17;10(1):13898
Abstract: In addition to its essential role in the physiological control of longitudinal growth, growth-hormone (GH) is endowed with relevant metabolic functions, including anabolic actions in muscle, lipolysis in adipose-tissue and glycemic modulation. Adult obesity is known to negatively impact GH-axis, thereby promoting a vicious circle that may contribute to the exacerbation of the metabolic complications of overweight. Yet, to what extent early-overnutrition sensitizes the somatotropic-axis to the deleterious effects of obesity remains largely unexplored. Using a rat-model of sequential exposure to obesogenic insults, namely postnatal-overfeeding during lactation and high-fat diet (HFD) after weaning, we evaluated in both sexes the individual and combined impact of these nutritional challenges upon key elements of the somatotropic-axis. While feeding HFD per se had a modest impact on the adult GH-axis, early overnutrition had durable effects on key elements of the somatotropic-system, which were sexually different, with a significant inhibition of pituitary gene expression of GH-releasing hormone-receptor (GHRH-R) and somatostatin receptor-5 (SST5) in males, but an increase in pituitary GHRH-R, SST2, SST5, GH secretagogue-receptor (GHS-R) and ghrelin expression in females. Notably, early-overnutrition sensitized the GH-axis to the deleterious impact of HFD, with a significant suppression of pituitary GH expression in both sexes and lowering of circulating GH levels in females. Yet, despite their similar metabolic perturbations, males and females displayed rather distinct alterations of key somatotropic-regulators/ mediators. Our data document a synergistic effect of postnatal-overnutrition on the detrimental impact of HFD-induced obesity on key elements of the adult GH-axis, which is conducted via mechanisms that are sexually-divergent.
URI: http://hdl.handle.net/10668/3890
metadata.dc.relation.publisherversion: https://www.nature.com/articles/s41598-020-70898-y
metadata.dc.identifier.doi: 10.1038/s41598-020-70898-y
ISSN: 2045-2322 (Online)
Appears in Collections:01- Artículos - Hospital Reina Sofía
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba

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