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Title: ELOVL6 Genetic Variation Is Related to Insulin Sensitivity: A New Candidate Gene in Energy Metabolism
Authors: Morcillo, Sonsoles
Martín Núñez, Gracia Mª
Rojo Martínez, Gemma
Almaraz, Mª Cruz
García Escobar, Eva
Mansego, Mª Luisa
de Marco, Griselda
Chaves, Felipe J.
Soriguer, Federico
metadata.dc.contributor.authoraffiliation: [Morcillo,S; Martín Núñez,GM; Rojo Martínez,G; Almaraz,MC; García Escobar,E; Soriguer,F] Endocrinology and Nutrition Service, Hospital Carlos Haya, Málaga, Spain.[Morcillo,S; Martín Núñez,GM; Rojo Martínez,G; Almaraz,MC; García Escobar,E; Mansego,ML; de Marco,G; Chaves,FJ; Soriguer,F] CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) of the Instituto de Salud Carlos III, Barcelona, Spain. [Mansego,ML; de Marco,G; Chaves,FJ] Unidad de Genotipado y Diagnóstico Genético, Hospital Clinic Research Foundation Valencia-INCLIVA, Valencia, Spain.
Keywords: Acetiltransferasas;Metabolismo Energético;Genotipo;Resistencia a la Insulina;Polimorfismo de Nucleótido Simple;Estudios Prospectivos
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Acyltransferases::Acetyltransferases
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Energy Metabolism
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies
Issue Date: 20-Jun-2011
Publisher: Public Library of Science
Citation: Morcillo S, Martín-Núñez GM, Rojo-Martínez G, Almaraz MC, García-Escobar E, Mansego ML, et al. ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism. PLoS One. 2011;6(6):e21198
Abstract: BACKGROUND: The elongase of long chain fatty acids family 6 (ELOVL6) is an enzyme that specifically catalyzes the elongation of saturated and monounsaturated fatty acids with 12, 14 and 16 carbons. ELOVL6 is expressed in lipogenic tissues and it is regulated by sterol regulatory element binding protein 1 (SREBP-1). OBJECTIVE: We investigated whether ELOVL6 genetic variation is associated with insulin sensitivity in a population from southern Spain. DESIGN: We undertook a prospective, population-based study collecting phenotypic, metabolic, nutritional and genetic information. Measurements were made of weight and height and the body mass index (BMI) was calculated. Insulin resistance was measured by homeostasis model assessment. The type of dietary fat was assessed from samples of cooking oil taken from the participants' kitchens and analyzed by gas chromatography. Five SNPs of the ELOVL6 gene were analyzed by SNPlex. RESULTS: Carriers of the minor alleles of the SNPs rs9997926 and rs6824447 had a lower risk of having high HOMA_IR, whereas carriers of the minor allele rs17041272 had a higher risk of being insulin resistant. An interaction was detected between the rs6824447 polymorphism and the intake of oil in relation with insulin resistance, such that carriers of this minor allele who consumed sunflower oil had lower HOMA_IR than those who did not have this allele (P = 0.001). CONCLUSIONS: Genetic variations in the ELOVL6 gene were associated with insulin sensitivity in this population-based study.
metadata.dc.identifier.doi: 10.1371/journal.pone.0021198
ISSN: 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga

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